Mechanisms of asthma and allergic inflammationParental tobacco smoking is associated with augmented IL-13 secretion in children with allergic asthma
Section snippets
Patients
The study population consisted of 24 atopic asthmatic schoolchildren (age, 6-16 years) attending the Allergy Clinic of the Department of Pediatric Pneumonology and Allergy of the Medical University Children's Hospital in Warszawa. Inclusion criteria were mild-to-moderate stable asthma, a positive skin prick test response to at least one common aeroallergen, and an FEV1 value of greater than 75% of predicted value. Asthma severity was classified by using a modified version of the 1997 National
IL-13 is highly expressed in NPAs in children with allergic asthma
IL-13 concentrations in NPAs obtained from children with allergic asthma were increased compared with those seen in the control group (P = .005, Mann-Whitney test; Table II and Fig 1). In contrast, a decreased level of IFN-γ was detected in asthmatic versus control patients (P = .0008). All cytokines were detected more frequently in asthmatic patients than in control subjects (Table II), but the difference was statistically not significant (χ2 test). We determined also the IL-5/IFN-γ,
Discussion
ETS, or passive smoking, has been demonstrated to be causally associated with a large number of human diseases, although the evidence is sometimes conflicting and the tobacco industry has tried to cover up research data over the past 30 years. In adults ETS exposure has been shown to be related to respiratory symptoms, bronchial asthma, a significant impairment of lung function, and increased bronchial responsiveness. Because the consequences of ETS exposure at the workplace seemed to be more
References (39)
IL-12/IL-13 axis in allergic asthma
J Allergy Clin Immunol
(2001)- et al.
Comparison of three methods for respiratory virus detection between induced sputum and nasopharyngeal aspirate specimens in acute asthma
J Virol Methods
(2002) Use of induced sputum to examine airway inflammation in childhood asthma
J Allergy Clin Immunol
(1998)- et al.
Respiratory health effects of exposure to environmental tobacco smoke
Respirology
(2003) - et al.
Prenatal and postnatal environmental tobacco smoke exposure and children's health
Pediatrics
(2004) - et al.
Health effects of passive smoking. 5. Parental smoking and allergic sensitisation in children
Thorax
(1998) - et al.
The role of cigarette smoke in the pathogenesis of asthma and as a trigger for acute symptoms
Curr Opin Pulm Med
(1999) - et al.
Immune mechanisms of childhood asthma
Thorax
(1999) - et al.
Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma
J Exp Med
(2002) Interleukin-13 in asthma pathogenesis
Immunol Rev
(2004)
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
J Clin Invest
Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity
J Immunol
Noninvasive assessment of airway inflammation in children: induced sputum, exhaled nitric oxide, and breath condensate
Eur Respir J
Inflammation in childhood asthma and other wheezing disorders
Pediatrics
Airway inflammation in children with difficult asthma: relationships with airflow limitation and persistent symptoms
Thorax
Maternal smoking in pregnancy alters neonatal cytokine responses
Allergy
Second-hand smoke increases bronchial hyperreactivity and eosinophilia in a murine model of allergic aspergillosis
Clin Dev Immunol
Interleukin-18 levels in induced sputum are reduced in asthmatic and normal smokers
Clin Exp Allergy
Cited by (70)
The Genetics of Allergic Disease and Asthma
2016, Pediatric Allergy: Principles and Practice: Third EditionStrategies targeting the IL-4/IL-13 axes in disease
2015, CytokineCitation Excerpt :BAL IL-13 expression is also stimulated by allergen challenge in asthmatics [55,60]. Cigarette smoke-exposed pediatric asthmatics have been shown to have further elevations in IL-13 protein expression compared to non-smoke exposed pediatric asthmatics [61]. A variety of different cells can act as sources of IL-4 and IL-13 in the asthmatic lung (Fig. 1).
Environmental Interventions for Asthma
2022, Seminars in Respiratory and Critical Care MedicineInterleukin-13 and Immunohistochemical Study of Iraqi Patients with Thyroid Goiter
2022, International Journal of Drug Delivery TechnologyApplication of Biomarkers in Assessing Health Risk of Indoor Air Pollutants
2022, Handbook of Indoor Air QualityFactors influencing the determination of angiotensin-converting enzyme (ACE) in pulmonary and extrapulmonary diseases
2021, Zentralblatt fur Arbeitsmedizin, Arbeitsschutz und Ergonomie
Supported by research grants from the Medical University of Warsaw (1W34/W1/1998-2000 and 1W34/W2/2003-2005).
- ∗
Dr Feleszko is on a leave of absence at the Department of Pediatric Pneumology and Immunology, Charité Universitäts Medizin, Berlin, Germany.