Original Pre-Clinical SciencePre-transplant antibodies to Kα1 tubulin and collagen-V in lung transplantation: Clinical correlations
Section snippets
Methods
The Washington University Human Studies Committee approved this study. All patients were included in the study after informed consent.
Increased prevalence of Abs to SAgs Kα1T, Col-I, and Col-V in IPF, CF, and COPD patients listed for LTx
Previous studies have demonstrated a significant correlation between the development of Abs to SAgs and development of DSAs and BOS after human LTx.16 To determine the incidence of pre-existing Abs to SAgs in patients listed for LTx, we analyzed sera from 317 patients listed for LTx at Washington University and Cleveland Clinic between 2000 and 2011. As reported in Table 1, 29 of 161 COPD (18.01%; p = 0.033), 17 of 50 IPF (34%; p = 0.0006), 16 of 55 CF (29.1%; p = 0.0023), and 10 of 51 patients
Discussion
Studies from our laboratory, and others, have demonstrated that humoral and cellular immunity to the lung-associated SAgs, Kα1T and Col-V, can pre-dispose patients to develop BOS.9, 11, 19, 20 In a previous report from our center of 142 patients, we demonstrated that patients with pre-existing Abs to lung-associated SAgs have an increased risk of developing PGD, DSAs, and BOS.16 However, because of our limited sample size, we were unable to comment on the incidence of PGD, DSA formation, and
Disclosure statement
The authors thank Billie Glasscock for her help in preparing this manuscript.
This work was supported by National Institutes of Health grant HL-056643 and the BJC Foundation (T.M.).
None of the authors has a financial relationship with a commercial entity that has an interest in the subject of the presented manuscript or other conflicts of interest to disclose.
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