Archival ReportMeta-Analysis of 15 Genome-Wide Linkage Scans of Smoking Behavior
Section snippets
Study Samples
To identify existing genome-wide linkage studies on smoking behavior, we conducted a computerized literature search of the PubMed database with the following keywords and subject terms: “linkage,” “smoking,” “nicotine dependence,” “genome-wide,” or “genomewide.” Review articles on genetics of smoking behavior were also screened. The genome scans included in the current GSMA were required to meet the following criteria: 1) whole genome linkage scan on smoking-related traits performed in humans;
Results
First, we performed the primary 30-cM bin width GSMA over all independent genome scans on smoking behavior, encompassing 3404 families with 10,253 genotyped subjects. Figure 1 illustrates the weighted and unweighted pSR for all bins across the genome. The full details of genetic regions showing bins with nominal significance in weighted analysis are shown in Table 2, and the unweighted analysis results are also included as a comparison with weighted analysis. The strongest evidence for a
Discussion
The current GSMA, which included 3404 families with 10,253 subjects, has identified many regions with varying degrees of evidence of linkage for smoking behavior. In the primary 30-cM GSMA of combined smoking behavior, genome-wide suggestive linkage was detected at chromosome 17q24.3-q25.3. The fact that we did not identify any bins with genome-wide significant evidence for linkage in the primary analysis might imply the possible relatively higher genetic heterogeneity due to a variety of
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