Original articleGeneral thoracicSurvival and Outcomes of Pulmonary Resection for Non-Small Cell Lung Cancer in the Elderly: A Nested Case-Control Study
Section snippets
Patients
This is a nested case-control study between January 1998 and January 2005. A case-control analysis was used to determine and evaluate preoperative risk factors and a matched cohort analysis was used to examine differences in survival. A consecutive series of elderly patients who met this study’s entry criteria comprised the patients in one part of this study. Younger patients (less than 70 years of age) who had complete pulmonary resection (R0) during the time interval of the study were
Results
There were 726 patients; 363 were elderly and 363 patients served as younger matched controls. Among the elderly, 191 patients were 70 to 74 years old, 121 were between 75 and 79, and 51 were octogenarians. Controls were matched from the database based on FEV1% of predicted, ECOG performance status, stage, type of tumor, and the type of pulmonary resection performed.
Table 1 compares the patient characteristics of the elderly with their younger counterparts. The male to female ratio differs
Comment
Lung cancer remains a pandemic and is the most common cause of cancer death in the United States and world wide. In 2005, there will be about 173,000 new cases of lung cancer, accounting for 13% of all cancers [10].
The average age of patients diagnosed with lung cancer is 63 years. Less than 3% of patients who develop lung cancer are 45 years or younger [10]. Given these facts and the increasing age of the population of the United States, more and more elderly Americans will present to their
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