We identified references for this Personal View by searching PubMed with the search terms “over diagnosis”, “over treatment”, and “cancer”. We looked at articles published in English between Jan 1, 1985, and the date of our last search (Nov 25, 2013). We also used and shared our extensive databases, and individual authors were assigned to review each organ subtype discussed in this Personal View. There were more references than could be accommodated by the manuscript reference limit, so the
Personal ViewAddressing overdiagnosis and overtreatment in cancer: a prescription for change
Introduction
On March 8–9, 2012, the National Cancer Institute convened a meeting to assess the problem of cancer overdiagnosis, which occurs when tumours that would otherwise not become symptomatic are identified and treated. When this overdiagnosis is not recognised, it can lead to overtreatment. Participants of the meeting agreed that with the deployment of increasingly sensitive imaging tests, more lesions are being identified and labelled as cancer. This Personal View describes the initial steps to address the increasing problem of overdiagnosis and overtreatment.
The word cancer encompasses a range of disorders, from those that are always lethal if left untreated (or even if treated) to indolent lesions with extremely low potential for metastatic progression and death.1 Several other diseases show a similar range of severity—eg, diabetes can progress slowly or rapidly, as can rheumatoid arthritis, hepatitis, coronary artery disease, and inflammatory bowel disease. Unfortunately, when patients hear the word cancer, most assume they have a disease that will progress, metastasise, and cause death. Many physicians think so as well, and act or advise their patients accordingly. However, since many tumours do not have the unrelenting capacity for progression and death, new guidance is needed to describe and label the heterogeneous diseases currently referred to as cancer.
Section snippets
Benefits of screening, according to cancer type
Screening is based on the assumption that cancer has an orderly and gradual progression (figure 1A). Good survival outcomes for patients with the earliest stages of disease led to the conclusion that detection of cancer at an early stage would dramatically reduce cancer mortality. For some cancers, incidence of disease dropped after screening was initiated (eg, cervical and colon cancer), but it increased for others (eg, breast and prostate cancer).1 In breast and prostate cancer, for example,
The concept of the IDLE lesion
Screening undoubtedly detects indolent disease, best exemplified in prostate cancer,16, 17 breast cancer,1 and even lung cancer.18, 19, 20 This detection of indolent disease is mainly due to the inherent tendency of all screening tests to preferentially detect slower growing cancers because more rapidly growing cancers are more likely to present between screens. Indolent disease might account for 15–75% of all cancers, depending on organ type.8 Disease-based screening and diagnostic scans for
A call for change
We attended the March 8–9, 2012, US National Cancer Institute multidisciplinary brainstorming meeting and agreed that it was important for the medical community to recognise that cancer overdiagnosis is an increasingly common problem. We, along with the other participants, made the following recommendations for consideration and dissemination (summarised in panel).
Conclusion
In conclusion, we have discussed the harms that are accruing from a one-size-fits-all approach to cancer screening and overuse of the term cancer. To reduce the substantial harm from this approach and to reduce the overall burden of cancer, the wide range of behaviours and outcomes associated with what is currently called cancer should be recognised. As a collective community of clinicians, researchers, patients, and stakeholders, the challenge is to redefine cancer based on its behaviour, use
Search strategy and selection criteria
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