Hypoxia-inducible factor 1: master regulator of O2 homeostasis

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Abstract

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential homeostatic responses to reduced O2 availability in mammals. Recent studies have provided insights into the O2-dependent regulation of HIF-1 expression, target genes regulated by HIF-1, and the effects of HIF-1 deficiency on cellular physiology and embryonic development.

Abbreviations

ARNT aryl hydrocarbon nuclear translocator
bHLH basic helix-loop-helix
EPO erythropoietin
HRE hypoxia-response element
TADs transcriptional activation domains
VEGF vascular endothelial growth factor

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