Elsevier

Fibrinolysis

Volume 10, Issue 4, July 1996, Pages 215-237
Fibrinolysis

Invited Review: State Of The Art Lecture At The 13th International Congress On Fibrinolyisis And Thrombolysis, Barcelona, 1996
Signal transduction and the u-PA/u-PAR system

https://doi.org/10.1016/S0268-9499(96)80018-XGet rights and content

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      Tanaka et al31 showed that ROS caused uPA activation in gingival fibroblast cells. The other authors demonstrated that the genes participating in the up-regulation of uPA and its receptor uPAR had SOX-responsive elements such as activator protein-1 and/or nuclear factor-kappaB binding sites in their promoter/enhancer regions.32 Thus, an increased uPA/suPAR level might reflect a higher synthesis rate because of inflammatory state and SOX combined with a decreased filtration of these molecules in the patients with renal insufficiency.

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