Alcoholic beverages consumption and lung cancer cell types among women in Poland
Introduction
The relationship between alcohol consumption and lung cancer has been examined in cohort, case-control and ecological studies, although a confounding factor, such as cigarette smoking, was not always controlled [13].
The association of alcohol with different histologic types of lung cancer in women has not received much attention in the studies conducted so far.
This paper reports the results from one part of the case-control study examining, among variety of suspected risk factors, the importance of alcoholic beverages drinking for specific lung cell types in women, which was undertaken in Cracow, Poland, between 1991 and 1997.
Section snippets
Material and methods
The cases were 242 women with primary carcinoma of the lung (9th Revision, ICD 162), histologically verified, who were admitted to the M. Sklodowska-Curie Memorial Institute in Cracow, Poland.
Squamous-cell carcinoma accounted for 37% of all cases, 36% were small cell carcinoma, 21% adenocarcinoma and 6% were mixed and other types.
The controls were 352 healthy women randomly selected from next-of-kin of other patients without tobacco related cancer, who were admitted to the M. Sklodowska-Curie
Results
The median age for squamous-cell carcinoma was 62.0 years, for small cell carcinoma 58.0 years, for adenocarcinoma 59.0 years, and the median age for all cases was 61.0. The median age for controls was 58.0.
Table 1 shows the relation of consumption frequency of different alcoholic beverages to different histologic types and to all combined histologic types of lung cancer.
For cases who were vodka drinkers the following distribution was observed, 72.4% small cell carcinoma; 71.1% adenocarcinoma;
Discussion
Association between alcohol consumption and lung cancer has not been described consistently in literature. Also relationship between alcohol and specific histologic types of lung cancer has not been well-documented in literature. It has generally been caused by the limited statistical power of most studies to stratify by cell type.
From 19 cohort studies examined for relationship between alcohol consumption and the risk of lung cancer, only eight were controlled for tobacco smoking [2], [14],
References (21)
- et al.
Alcohol and beer consumption in relation to cancers of bowel and lung. An extended correlation analysis
J. Chron. Dis.
(1982) - et al.
Alcohol, beer and lung cancer in postmenopausal women. The Iowa Women's Health Study
Ann. Epidemiol.
(1992) - et al.
Risk factors for lung cancer among women in Poland
Lung Cancer
(1997) - et al.
Alcohol consumption and lung cancer in white males
Cancer Causes Control
(1992) - et al.
Diet and alcohol consumption and lung cancer risk in the New York State Cohort (United States)
Cancer Causes Control
(1997) - et al.
Statistical methods in cancer research. Volume 1-the analysis of case-control studies
Lyon IARC
(1980) - et al.
The effect of alcohol on the risk of lung cancer in Uruguay
Cancer Epiemiol. Biomarkers Prev.
(1993) - Food, nutrition and the prevention of cancer: a global perspective. Washington: World Cancer Fund/American Institute...
- et al.
Drinking and mortality. The Framingham study
Am. J. Epidemiol.
(1984) - et al.
Alcohol mortality: a ten year Kaiser–Permanente experience
Ann. Intern. Med.
(1981)
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