ArticlesAntibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease
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2021, Journal of the Formosan Medical AssociationThe prognostic significance of glutamic acid decarboxylase antibodies in patients with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation
2019, Diabetes and MetabolismCitation Excerpt :Glutamic acid decarboxylase is an enzyme mainly expressed in pancreatic β cells and neuron cells that catalyses the conversion of glutamic acid to γ-aminobutyric acid (GABA). Elevated GADA is a specific immunologic marker for the diagnosis of T1D [4,5], and may be elevated before the clinical diagnosis. However, GADA positivity has been observed in some non-diabetic populations and is of unclear significance in this setting [8,12,13].
Prevalence of double diabetes in youth onset diabetes patients from east Delhi and neighboring NCR region
2018, Diabetes and Metabolic Syndrome: Clinical Research and ReviewsCitation Excerpt :However Reinehr et al. who reported a higher prevalence of double diabetes (32%) have not mentioned the duration of diabetes in their study. It is unclear whether shorter duration of diabetes in these subjects resulted in a higher rate of antibody positivity [15,16], which might be an important factor underlying the difference in prevalence of double diabetes from our study. When the subjects in our study were analyzed considering the duration of diabetes we found highest antibody positive with shorter duration of diabetes mellitus.
Could ZnT8 antibodies replace ICA, GAD, IA2 and insulin antibodies in the diagnosis of type 1 diabetes?
2018, Current Research in Translational MedicineCitation Excerpt :Interestingly, in our population, ZnT8ab was significantly more found in females and it was different from the results obtained in the study of Salonen and Knip, which did not show any significant difference between the ZnT8ab prevalence in both boys and girls [26]. We observed that GADab was significantly more present in the beginning of T1D and these results were in accordance with Tuomilehto et al., Tobon et al. and Chan et al. who showed a higher prevalence of GADab in young diagnosed patients [31–33], but controverted those of Serrano-Ríos et al. who did not find any correlation between the GADab and the diabetes duration [34]. The IAab was significantly more present in young diagnosed patients, our results were in accordance with the studies of Tung et al. and Delgado-Charro [35,36].