Preliminary CommunicationCLINICAL EXPERIENCE WITH 99mTc-HEXAMETHYLPROPYLENE-AMINEOXIME FOR LABELLING LEUCOCYTES AND IMAGING INFLAMMATION
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2023, Current Problems in CardiologyCitation Excerpt :One of the earliest nuclear imaging techniques utilized Gallium (Ga) radionuclide, specially Ga-67, which is predominantly taken up by lymphocytes and helps localize infection/inflammation.31,32 Later, leucocyte labeling was achieved first using indium (In-111) and later Technetium (Tc-99m) HMPAO.33,34 Since their discovery, both In-111 and Tc-99m leucocyte imaging have been used in CNS infection, pulmonary infection, detection of inflammatory bowel disease, prosthetic joint infection, osteomyelitis, cardiac and vascular graft prosthesis infections.35,36
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2017, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :The presence of neutrophils at the inflammation spot, though not proved experimentally in the frame of the present work, was clearly shown with previous histological studies which revealed that inflammation foci generated by turpentine oil are highly infiltrated by neutrophils on the first day after injury [35,37]. On the other hand, 99mTc- or 111In- labeled autologous neutrophils and other human leukocytes have been used as inflammation imaging radiopharmaceuticals for many years, since they are chemoattracted and gathered in inflamed regions of organs and tissues [38,39]; in our opinion, this well-established association between migration of human leukocytes to inflamed foci, during the early inflammation stages, and imaging of inflammation at a clinical level via administration of autologous leukocytes seems to provide further basis to our speculation. A rather high ratio value of accumulated radioactivity in inflammation versus normal tissue at 30 min p.i. (3.9) was earlier observed in biodistribution studies conducted by our team with [99mTc]N1, though much lower than the value observed in the present study with [99mTc]C1 (9.15).