HypothesisROLE OF PLASMA EXUDATION IN ASTHMATIC AIRWAYS
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Cited by (169)
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2022, Journal of Allergy and Clinical ImmunologyPulmonary delivery nanomedicines towards circumventing physiological barriers: Strategies and characterization approaches
2022, Advanced Drug Delivery ReviewsAirways exudation of plasma macromolecules: Innate defense, epithelial regeneration, and asthma
2019, Journal of Allergy and Clinical ImmunologyCitation Excerpt :An early demonstration of prompt challenge-induced microvascular-epithelial exudation in guinea pig tracheobronchial airways suggested that plasma macromolecules appeared on the mucosal surface independent of their charge and size.29 The indiscriminate microvascular-epithelial passage of macromolecules explains why the process is called exudation rather than transudation, the latter name emphasizing fluid movement.35-37 Thus different-sized plasma proteins have appeared on challenged but intact guinea pig and human airway mucosal surfaces in nearly the same concentration ratios as occur in circulating blood.24,29,31,38
Brain natriuretic peptide: Much more than a biomarker
2016, International Journal of CardiologyCitation Excerpt :This discrepancy may be explained by the fact that BNP probably does not act as a direct bronchodilator on ASM [56]. In effect, it has been suggested that the ability of BNP to improve lung function in vivo may be related to other actions, such as the reduction of airways microvascular leakage and plasma exudation into the airways [79,80]. The bronchodilator effect of BNP has also been investigated in human small airways by using PCLS preparations and it has been compared with the effect elicited by PL-3994 [77].
Apelin attenuates UVB-induced edema and inflammation by promoting vessel function
2011, American Journal of PathologyCitation Excerpt :Acute photodamage of the skin is characterized by epidermal hyperplasia, erythema, and edema formation. Edema is caused by accumulation of extracellular fluid due to excess leakage from hyperpermeable blood vessels33 and by a failure of lymphatic vessels to sufficiently drain the fluid from the interstitium.12 Moreover, the dysfunction of lymphatic vessels also results in reduced clearance of macrophages from the tissue via lymphatic drainage,34 suggesting that the function of lymphatic vessels is profoundly related to the process of UVB-induced inflammation.
The effect of airway remodelling on airway hyper-responsiveness in asthma
2011, Respiratory MedicineCitation Excerpt :However, the improvement in airway distensibility, which was of borderline significance, suggests that airway distensibility, measured by FOT, is partly influenced by steroid-responsive inflammation. The precise mechanism of this is unclear but it is likely that the steroid-responsive components of inflammation, including oedema and plasma exudate resulting from microvascular leakage,31,32 thicken the airway walls thereby reducing airway distensibility. This is supported by the results of imaging studies in which wall thickness decreases with ICS.19