NewsPhotodynamic therapy begins to shine
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Photodynamic Therapy Interventions in Facial Photodamage: A Systematic Review
2018, Actas Dermo-SifiliograficasCitation Excerpt :Skin collagen is also affected by UV-induced matrix metalloproteinases (MMP)11 such as MMP-1 (fibroblast collagenase), MMP-9 (gelatinase) and MMP-3 (stromelysin),10,12 and solar elastosis seems to be a consequence of an increased production of elastic fibers and elastin degradation by MMP-12 (human macrophage metalloelastase).10,13–15 Photodynamic therapy (PDT) is a selective therapeutic modality that combines an oxygen rich environment and a light source that stimulates a photosensitizing agent to produce singlet oxygen which is highly toxic to the cells.16,17 Porphyrins and particularly hematoporphyrins (e.g.: photofrin) were the first intravenous substances used for PDT, characterized by their long-term accumulation in target tissue that required rigorous photoprotection for several weeks after administration.17
Photodynamic therapy in dermatology
2006, Actas Dermo-SifiliograficasPhotodynamic Therapy
2006, Cutaneous and Cosmetic Laser SurgeryAn approach to enhancing the phototoxicity of a novel hypocrellin congener to MGC803 cells
2001, Dyes and PigmentsLocalization of the peptide transporter PEPT2 in the lung: Implications for pulmonary oligopeptide uptake
2001, American Journal of PathologyCitation Excerpt :Carbon monoxide is discussed as a marker for chronic airway inflammations such as asthma.39 δ-ALA’s therapeutical relevance is based on photodynamic therapy40,41 that uses accumulation of porphyrins after administration of δ-ALA to induce tissue necrosis and apoptosis. As δ-ALA is discussed for aerosol administration in lung tumors we provide data for the possible uptake mechanisms and determine the cellular site of uptake in airway tissues.
Mechanisms of action of photodynamic therapy with verteporfin for the treatment of age-related macular degeneration
2000, Survey of Ophthalmology