Elsevier

The Lancet

Volume 351, Issue 9114, 16 May 1998, Page 1496
The Lancet

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Photodynamic therapy begins to shine

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Cited by (30)

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    Skin collagen is also affected by UV-induced matrix metalloproteinases (MMP)11 such as MMP-1 (fibroblast collagenase), MMP-9 (gelatinase) and MMP-3 (stromelysin),10,12 and solar elastosis seems to be a consequence of an increased production of elastic fibers and elastin degradation by MMP-12 (human macrophage metalloelastase).10,13–15 Photodynamic therapy (PDT) is a selective therapeutic modality that combines an oxygen rich environment and a light source that stimulates a photosensitizing agent to produce singlet oxygen which is highly toxic to the cells.16,17 Porphyrins and particularly hematoporphyrins (e.g.: photofrin) were the first intravenous substances used for PDT, characterized by their long-term accumulation in target tissue that required rigorous photoprotection for several weeks after administration.17

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  • Localization of the peptide transporter PEPT2 in the lung: Implications for pulmonary oligopeptide uptake

    2001, American Journal of Pathology
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    Carbon monoxide is discussed as a marker for chronic airway inflammations such as asthma.39 δ-ALA’s therapeutical relevance is based on photodynamic therapy40,41 that uses accumulation of porphyrins after administration of δ-ALA to induce tissue necrosis and apoptosis. As δ-ALA is discussed for aerosol administration in lung tumors we provide data for the possible uptake mechanisms and determine the cellular site of uptake in airway tissues.

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