Research LettersS-adenosylmethionine concentrations in diagnosis of Pneumocystis carinii pneumonia
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Diagnosis of Pneumocystis pneumonia: Evaluation of four serologic biomarkers
2015, Clinical Microbiology and InfectionCitation Excerpt :These differences may be due to the use of distinct laboratory methodologies and sampling (high-performance liquid chromatography and plasma were used in previous studies instead of ELISA and serum) [29,30]. Additionally, this bias may be caused by differences in P. jirovecii burdens and by factors such as poor nutrition, medical conditions or other inherent variables (e.g. coexisting pulmonary malignancies), thus affecting the serum levels of this metabolite in a way that compromises its reliability as a diagnostic tool [24,29]. The high cost of the plasma SAM assay (US$300, €224.9 per sample specimen) is also an important limitation [29].
Nonmolecular methods for the diagnosis of respiratory fungal infections
2014, Clinics in Laboratory MedicineCitation Excerpt :Detection of markers of the disease in serum thus represents an attractive alternative strategy. In 2003, measurement of plasma S-adenosylmethionine concentrations was proposed as a diagnostic tool of PJP.100 Because P jirovecii is not able to synthesize this essential metabolic intermediate, plasma S-adenosylmethionine from the host serves as an exogenous source for the pathogen and accordingly is depleted during PJP infection.
Accuracy of β-D-glucan for the diagnosis of Pneumocystis jirovecii pneumonia: A meta-analysis
2013, Clinical Microbiology and InfectionCitation Excerpt :An incorrect clinical diagnosis of PCP could also be associated with failure to detect and treat other potentially serious conditions [3]. Some serum or plasma biomarkers have been studied with the aim of improving the diagnosis of PCP [9]. ( 1 → 3)-β-D-glucan (BDG) is a candidate such marker.
Pneumocystis jirovecii pneumonia in non-HIV-infected patients in the era of novel immunosuppressive therapies
2012, Journal of Infection and ChemotherapyPneumocystis pneumonia
2012, Sande's HIV/AIDS Medicine: Medical Management of AIDS 2013Pneumocystis pneumonia and measurement of S-adenosylmethionine plasma levels
2011, Journal of Infection