Elsevier

The Lancet

Volume 358, Issue 9295, 24 November 2001, Pages 1780-1781
The Lancet

Research Letters
Burkholderia cepacia complex genomovars and pulmonary transplantation outcomes in patients with cystic fibrosis

https://doi.org/10.1016/S0140-6736(01)06808-8Get rights and content

Summary

Burkholderia cepacia is a group of organisms that comprises seven genotypically distinct species (B cepacia genomovars I–VII), which are collectively known as the B cepacia complex. Preoperative infection with B cepacia is associated with a poor prognosis in lung transplant recipients with cystic fibrosis. Many centres do not, therefore, offer transplants to these individuals. Our aim was to ascertain whether or not post-transplant mortality is affected by pretransplant genomovar status. We studied archived isolates with PCR-based methods, and recorded excessive mortality in patients infected with B cepacia genomovar III, but not in those infected with other genomovars.

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