Elsevier

The Lancet

Volume 355, Issue 9218, 27 May 2000, Pages 1885-1886
The Lancet

Research Letters
Differential binding of mannose-binding lectin to respiratory pathogens in cystic fibrosis

https://doi.org/10.1016/S0140-6736(00)02297-2Get rights and content

Summary

We have found that mannose-binding lectin binds to Burkholderia cepacia, an important pathogen in patients with cystic fibrosis, and leads to complement activation, but that this is not the case for Pseudomonas aeruginosa, the more common colonising organism in this disease. We suggest that patients with cystic fibrosis with mannose-binding-lectin deficiency will be at particular risk of B cepacia colonisation.

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