Plasminogen Activators, Tissue Degradation, and Cancer

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This chapter discusses the role of plasminogen activators in various biological processes. In specific, it describes two types of plasminogen activators—namely, the urokinase-type plasminogen activator (u-PA) and the tissue-type plasminogen activator (t-PA), which are essentially different gene products. The amino acid sequences of these activators and nucleotide sequences of the corresponding cDNAs have largely been determined, and the cDNAs have been cloned using recombinant techniques. A variety of enzymatic as well as immunological assay and detection methods have also been developed that allows a precise quantification of the activators, a distinction between u-PA and t-PA, determination of whether an activator is present in its active or zymogen form, analysis of the kinetics of different steps of the cascade reaction, and immunocytochemical identification of u-PA and t-PA in tissue sections. Much of the studies on plasminogen activators and cancer has been guided by the hypothesis that proteolysis of the components of extracellular matrix, initiated by the release of plasminogen activator from the cancer cells, plays a decisive role for the degradation of normal tissue, and thereby for invasive growth and metastases.

References (1005)

  • B. Aasted

    Biochim. Biophys. Acta

    (1980)
  • B. Aasted

    Biochim. Biophys. Acta

    (1981)
  • Y. Abiko et al.

    Biochim. Biophys. Acta

    (1969)
  • J. Aggeler et al.

    Biochim. Biophys. Acta

    (1981)
  • J. Aggeler et al.

    Exp. Cell Res.

    (1982)
  • K. Alitalo et al.

    Adv. Cancer Res.

    (1982)
  • B. Åstedt

    Thromb. Res.

    (1979)
  • B. Åstedt et al.

    Thromb. Res.

    (1978)
  • B. Åstedt et al.

    Thromb. Res.

    (1979)
  • B. Åstedt et al.

    Eur. J., Cancer

    (1981)
  • T. Astrup et al.

    Arch. Biochem. Biophys.

    (1952)
  • J. Babnik et al.

    Mol. Immunol.

    (1983)
  • J.B. Baker et al.

    Cell

    (1980)
  • G. Balian et al.

    J. Biol. Chem.

    (1979)
  • L. Banyai et al.

    J. Biol. Chem.

    (1984)
  • L. Bányai et al.

    FEBS Lett.

    (1983)
  • BarlowG.H. et al.

    Thromb. Res.

    (1981)
  • P.A. Barouski et al.

    Biochem. Biophys. Res. Commun.

    (1980)
  • P.A. Barouski-Miller et al.

    J. Steroid Biochem.

    (1984)
  • W.H. Beers

    Cell

    (1975)
  • W.H. Beers et al.

    Cell

    (1975)
  • W.L. Bigbee et al.

    Biochim. Biophys. Acta

    (1978)
  • R. Biggs et al.

    Lancet

    (1947)
  • B.R. Binder et al.

    J. Biol. Chem.

    (1979)
  • A. Biörklund et al.

    Eur. J., Cancer

    (1980)
  • C. Biswas et al.

    Biochem. Biophys. Res. Commun.

    (1978)
  • P.H. Black

    Adv. Cancer Res.

    (1980)
  • A. Bollen et al.

    Biochem. Biophys. Res. Commun.

    (1980)
  • A. Bollen et al.

    Biochem. Biophys. Res. Commun.

    (1981)
  • F.M. Booyse et al.

    Thromb. Res.

    (1981)
  • E.D. Adamson et al.

    Mol. Cell. Biochem.

    (1981)
  • S.F. Adelman et al.

    J. Gen. Virol.

    (1980)
  • S.F. Adelman et al.

    Mol. Cell. Biol.

    (1981)
  • A.C. Aisenberg

    “The Glycolysis and Respiration of Tumors.”

    (1961)
  • K. Akazawa et al.

    Acta Physiol, hat.

    (1983)
  • O.K. Albrechtsen

    Acta Endocrinol.

    (1956)
  • O.K. Albrechtsen

    Br. J., Haematol.

    (1957)
  • O.K. Albrechtsen

    Acta Physiol. Scand.

    (1957)
  • R. Albrechtsen et al.

    Cancer Res.

    (1981)
  • S.Y. Ali et al.

    Biochem. J.

    (1968)
  • S.Y. Ali et al.

    Biochem. J.

    (1965)
  • K., Alkjaer T., Astrup (1957) Trans. Congr. Eur. Soc. Haematol, 6th pp....
  • N. Alkjaersig

    Biochem. J.

    (1964)
  • R.A. Allen et al.

    Thromb. Haemostasis

    (1981)
  • L.-O. Aimér et al.

    Thromb. Res.

    (1975)
  • A. Amery et al.

    Thromb. Diathes. Haemorrh.

    (1962)
  • P.A. Andreasen et al.

    EMBO J.

    (1984)
  • N. Aoki

    J. Biochem.

    (1974)
  • N. Aoki et al.

    J. Lab. Clin. Med.

    (1971)
  • N. Aoki et al.

    Am. J., Physiol.

    (1972)
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