Solid Organ Transplantation: The LungNational Transplantation Pregnancy Registry: Outcomes of Pregnancies in Lung Recipients 1
Section snippets
Materials and Methods
Female lung transplant recipients who had been pregnant were identified from US transplant centers by transplant coordinators, physicians, or self-report. Data collection includes completion of a questionnaire by the recipient supplemented by telephone interviews, with additional information provided by the transplant center. Case number 5 was previously reported.[4]
Results
The mean age at first transplant was 26.7 years, the mean transplant interval (time from transplant to conception) was 2.0 years, and the mean age at conception was 28.7 years. The six pregnancies resulted in three therapeutic abortions and three livebirths. There were no miscarriages, stillbirths, or ectopic pregnancies. Maternal comorbid factors, complications, and newborn outcomes are detailed in Table 1. Briefly, the mean gestational age was 33 weeks and the mean birthweight 2202 g. There
Discussion
From this relatively small experience, female lung transplant recipients may have increased risks from pregnancy when compared to other solid organ recipients. These pregnancies must be considered high risk and require heightened communication between the obstetrical and transplant teams. A low threshold should be considered for rejection and infection.4, 5Because of the small numbers and the lack of similarities among these lung recipients and their pregnancies, it is difficult to formulate
Acknowledgements
The authors acknowledge Lisa Coscia, RN, BSN for her assistance with the preparation of this manuscript. Additionally, the authors would like to thank the transplant coordinators, physicians, and recipients who have contributed their time and information to the registry.
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Supported by grants from Sandoz Transplant, a Division of Novartis Pharmaceuticals Corp, Fujisawa USA, Inc, and Roche Laboratories Inc.