Original researchAsthma symptoms, severity, and drug therapy: a prospective study of effects on 2205 pregnancies☆
Section snippets
Materials and methods
Pregnant women were recruited from 56 obstetric practices and 15 clinics associated with six hospitals in Connecticut and Massachusetts. Exclusion criteria included being more than 24 weeks pregnant at interview, having insulin-dependent diabetes mellitus, not speaking English or Spanish, and intending to terminate the pregnancy.
Between April 1997 and June 2000, 11,484 women were screened for eligibility; all women with a history of physician-diagnosed asthma (n = 1343) and a simple random
Results
The distribution of study population characteristics by asthma status is shown in Table 1. rate than expected in the general pregnant population. The largest proportion of women had no asthma symptoms or treatment during their pregnancy (44.4%), one third (32.2%) had intermittent asthma, and almost a quarter of women (23.4%) were in higher-severity groups. Having an asthma diagnosis and having more severe asthma symptoms and treatment during pregnancy seems related to younger age, not being
Discussion
This study examines the independent associations of asthma diagnosis, severity, symptoms, treatment, and medication type with two different perinatal outcomes (preterm delivery and fetal growth assessed by IUGR). We found a modest increased risk of preterm delivery in women with an asthma diagnosis, but this was not distinguishable from chance when other risk factors were considered. No evidence of a relationship between preterm delivery and asthma symptoms or severity was observed.
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Chronic Management of Asthma During Pregnancy
2023, Immunology and Allergy Clinics of North AmericaLongitudinal Analysis of Lung Function in Pregnant Women with and without Asthma
2021, Journal of Allergy and Clinical Immunology: In PracticeCitation Excerpt :Lung function may affect perinatal outcomes, with FEV1 in women with asthma negatively associated with gestational hypertension, preterm birth, and fetal growth.11,12 Notably, perinatal outcomes were not associated with other measures of asthma symptom control during pregnancy (ie, symptoms, activity limitation, sleep loss) in this study,11 although an earlier study has suggested that daily asthma symptoms are related to risk of intrauterine growth restriction.13 This highlights the significance of monitoring lung function during pregnancy, particularly in women with asthma, who are at increased risk of adverse perinatal outcomes and in whom the course of asthma is unpredictable during pregnancy.14-17
Asthma in Pregnancy
2021, Encyclopedia of Respiratory Medicine, Second EditionThe management of asthma during pregnancy
2021, Clinical Pharmacology During PregnancyOral Corticosteroids and Risk of Preterm Birth in the California Medicaid Program
2021, Journal of Allergy and Clinical Immunology: In PracticePerinatal Outcomes Associated with Maternal Asthma and Its Severity and Control During Pregnancy
2020, Journal of Allergy and Clinical Immunology: In Practice
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This work was supported by grants AI41040 and DA05484 from the National Institutes of Health.
The authors thank the following for providing patient access to this study: Baystate Health System, Massachusetts: R. Burkman, MD, K. Troczynski, RN, P. O'Grady, MD; Bridgeport Hospital, Connecticut: E. Luchansky, MD, I. San Pietro, J. Collins, R. Torres, C. Presnick; Danbury Hospital, Connecticut: L. Silberman, MD; Hartford Hospital, Connecticut: S. Curry, MD, C. Mellon, MS; St. Raphael Hospital, Connecticut: W. Reguero, MD, B. McDowell, MD; Yale-New Haven Hospital, Connecticut: J. Coppel, MD, A. Somsel, S. Updegrove, MD, as well as many others in labor and delivery and neonatology in these hospitals. We also recognize the assistance of numerous staff at 56 private obstetric practices affiliated with the hospitals.