Original articleNon-heme (Fe3+) in the lung increases with age in both humans and rats☆
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Cigarette smoke-induced toxicity consequences of intracellular iron dysregulation and ferroptosis
2021, Life SciencesCitation Excerpt :Cigarette smoke seems to hurt the health and function of respiratory epithelium [56,75]. Typically, the iron deposition in epithelial lung cells was augmented following rodent treatment to smoke [76,77]. Iron accumulation within the epithelial lung cells, alongside the enhanced expression of ferritin and divalent metal transporter 1 (DMT1), was observed in cigarette smoke extract as an in vitro smoke exposure model [77].
Smoking-induced iron dysregulation in the lung
2019, Free Radical Biology and MedicineCitation Excerpt :Cigarette smoke has a deleterious effect on the health and function of epithelial cells of the lung [63]. In general, exposure of rodent models to smoke increases the deposition of iron in lung epithelial cells [18,31,64]. Cigarette smoke extract (CSE), an in vitro model for smoke exposure largely increases the concentration of iron inside lung epithelial cells, along with increased ferritin and DMT1 expression [18].
Oxidative stress in COPD
2013, ChestCitation Excerpt :In addition, other sources of intracellular ROS include the cytoplasmic ROS-generating enzymes, such as NADPH oxidase (NOX) and the xanthine/xanthine oxidase system as well as the heme peroxidases, levels of which are elevated in broncholavage fluid and inflammatory cells within the airways of patients with COPD.20,21 The abundantly produced superoxide radical is a relatively weak oxidizing agent but is the precursor for other more damaging ROS species (Fig 1), such as the hydroxyl radical which is elevated in COPD,22 or the very powerful and damaging peroxynitrite radical formed by the rapid reaction of superoxide with nitric oxide.23 Similarly MPO, released from activated neutrophils which accumulate in the lungs of patients with COPD, produces very destructive hypochlorous acid.
Humic acid enhances cigarette smoke-induced lung emphysema in mice and IL-8 release of human monocytes
2011, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :Interestingly after exposure of rats to cigarette smoke, ferritin was increased in lavage and serum, and non-heme iron concentrations in the lung and liver tissue were increased as well [14]. Thus, notably, it is known that pulmonary levels of iron and ferritin increase with age in non-smoking humans as well as rodents, but specifically so in smoking humans [25]. Smoking, therefore, may be more toxic for older than young adult subjects, because ferritin was shown to release Fe2+ upon smoke exposure [37].
Integration of Genomic and Genetic Approaches Implicates IREB2 as a COPD Susceptibility Gene
2009, American Journal of Human GeneticsCitation Excerpt :Features of COPD recapitulate characteristics of the lung that may occur with aging. Deposition and accumulation of iron is associated with cellular senescence,22 and iron in the lung has been noted to increase with age in humans and rats.23 Cigarette smoking has been associated with higher accumulated iron levels in the lung.11,24,25
Down modulation of IFN-γ signaling in alveolar macrophages isolated from smokers
2009, Toxicology and Applied Pharmacology
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Supported in part by grants from the National Institutes of Health (HL-02655) and the North Carolina Lung Association.