Elsevier

The Annals of Thoracic Surgery

Volume 74, Issue 6, December 2002, Pages 2176-2177
The Annals of Thoracic Surgery

Case report
Diclofenac (voltaren)-induced pneumonitis after chest operation

https://doi.org/10.1016/S0003-4975(02)04173-5Get rights and content

Abstract

We report a rare case of nonsteroidal anti-inflammatory drug-induced pneumonitis in a 72-year-old man taking diclofenac for wound pain after pulmonary resection. The pneumonitis and pleural effusion were predominant on the operative side and resolved rapidly after the diclofenac was discontinued. The diagnosis of drug-induced pneumonitis was based on a lymphocyte stimulation test that was positive for diclofenac sodium and negative for other drugs. This case report demonstrated that surgeons should be aware of the possibility of pneumonitis induced by a nonsteroidal anti-inflammatory drug.

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Comment

Nonsteroidal anti-inflammatory drugs are widely used to treat many common conditions, but lung damage as a complication of NSAID is not well known. There is only one case report of diclofenac-induced pulmonary damage, described by Khalil and colleagues [1], who also provided a literature review of 23 cases of pneumonitis caused by other NSAID such as Sulindac, Naproxen, and Fenbufen . There have since been reported of pneumonitis induced by Mesalazine 2, 3, but the major underlying disease

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    (1999)
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