Original article: general thoracicSurgical resection of multifocal non-Small cell lung cancer is associated with prolonged survival
Section snippets
Population under study
A database analysis of our cardiothoracic surgery tumor registry was performed. Five hundred forty-eight patients underwent surgical resection of NSCLC with pathologically node-negative disease from January 1, 1994 to December 31, 1999. The surgical pathology reports of all patients identified by this database query were individually reviewed and the final pathologic staging was assigned using the 1997 revisions in the International System for Staging Lung Cancer. Patients with pathologically
Patient demographics
Five hundred forty-eight patients underwent complete surgical resection of NSCLC who were ultimately determined to have pathologically node-negative disease between January 1, 1994 and December 31, 1999 (Table 1). Two hundred eighty-eight patients were male (53%) and 260 patients (47%) were female. The mean age was 66.7 years old (± 9.8 years). The distribution of patients by pathologic stage was stage IA 273 (49.8%), stage IB 231 (42.2%), stage IIIA 27 (4.9%), and stage IV 17 (3.1%).
Comment
The optimal management of patients with multifocal non-small cell carcinoma remains controversial. Preoperatively, it is often difficult to determine if multiple lesions represent separate primary lung cancers or intrapulmonary metastases. This distinction can remain difficult even after pathologic examination of the surgical specimens when the histology of the lesions is the same. Martini and Melamed [7] described their experience with multifocal lung cancer and outlined their recommendations
References (12)
- et al.
Incidence of local recurrence and second primary tumors in resected stage I lung cancer
J Thorac Cardiovasc Surg
(1995) Revisions in the International System for Staging Lung Cancer
Chest
(1997)- et al.
Impact of comorbidity on survival after surgical resection in patients with stage I non-small cell lung cancer
J Thorac Cardiovasc Surg
(2002) - et al.
Multiple primary lung cancers
J Thorac Cardiovasc Surg
(1975) - et al.
Operative approach for multiple primary lung carcinomas
J Thorac Cardiovasc Surg
(1998) - et al.
Evaluation of TMN classification for lung carcinoma with ipsilateral intrapulmonary metastasis
Ann Thorac Surg
(1999)
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