EditorialThe role of mucus in fatal asthma
References (19)
The presence or absence of bronchial mucus in fatal asthma
J Allergy Clin Immunol
(1987)Goblet cell and mucin gene abnormalities in asthma
Chest
(2002)- et al.
An evaluation of the effect of nebulized N-acetylcysteine on sputum consistency
J Allergy
(1967) - et al.
Surveillance for asthma—United States, 1980–1999
MMWR Surveill Summ
(2002) - et al.
Long-term prognosis of near-fatal asthma. A 6-year follow-up study of 145 asthmatic patients who underwent mechanical ventilation for a near-fatal attack of asthma
Am Rev Respir Dis
(1992) - et al.
Respiratory arrest in near-fatal asthma
N Engl J Med
(1991) - et al.
Risk factors for near-fatal asthma. A case-control study in hospitalized patients with asthma
Am J Respir Crit Care Med
(1998) The pathology of asthma
APMIS
(1997)- et al.
The pathology of bronchial asthma
Arch Intern Med
(1922)
Cited by (43)
Eosinophil-mucus interplay in severe asthma: Implications for treatment with biologicals
2024, Allergology InternationalIL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation
2019, Journal of Allergy and Clinical ImmunologyCitation Excerpt :This combination of mucus overproduction and decreased clearance in our model is also associated with mucus plugging and significant airflow limitation (decrease in FEV0.1). Hypersecretion of mucus by goblet cells and elimination or dysfunction of ciliated cells in the lung also represent the primary mechanisms of airway obstruction and a leading cause of death in patients with asthma and COPD.68-73 Transcriptomic analysis also revealed that markers of matrix remodeling and fibrotic responses are induced in response to HDM exposure, which correlates with the increased presence of myofibroblasts in the alveolar region of the lung and is associated with increased lung stiffness (as shown by increased respiratory system resistance and respiratory system elastance values).
The Immune Basis of Allergic Lung Disease
2015, Comparative Biology of the Normal Lung: Second Edition