Pharmacology of serotonin as related to anesthesia
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Cited by (53)
Graphene/conducting polymer nano-composite loaded screen printed carbon sensor for simultaneous determination of dopamine and 5-hydroxytryptamine
2017, Sensors and Actuators, B: ChemicalCitation Excerpt :The determination of DA has been considered useful in the diagnosis of several diseases and hence makes it the choice of biologically and pharmacologically oriented research. Serotonin (5-hydroxytryptamine, 5-HT), is a biogenic monoamine neurotransmitter and neuromodulator [16] found in the human brain [17], which plays a pivotal role to control and regulate various physiological functions such as eating disorder, sleep, muscle contraction, sexual activity and thermoregulation as well as in psychopathological processes such as anxiety disorder, liver regeneration, infantile autism, alcoholism, obsessive-compulsive disorder and drug dependency [5,18]. 5-HT is synthesized in human system from an essential amino acid tryptophan by the enzyme tryptophan hydroxylase − I (TpH-1) and widely distributed in the central and peripheral nervous systems, smooth muscles, and platelets in the body.
The effect of ondansetron in preventing the hypotensive bradycardic events during shoulder arthroscopy done under interscalene block in the sitting position
2014, Egyptian Journal of AnaesthesiaCitation Excerpt :Increased epinephrine may be caused by decreased venous return due to sitting position and stimulation of the carotid baroreceptors (endogenous epinephrine). Hypovolemia not only causes stimulation of cardiac mechanoreceptors in the left ventricle that triggers the BJR and causes reflex bradycardia, vasodilatation and hypotension [19–22], but also results in the activation of thrombocytes to release serotonin which triggers chemoreceptors in the wall of the heart [12,21,23]. Furthermore, stimulation of 5-HT3 receptors, that are G protein coupled, ligand-gated, fast-ion channels, increases the activity of the vagal nerve [21].
Polymelamine modified edge plane pyrolytic graphite sensor for the electrochemical assay of serotonin
2014, TalantaCitation Excerpt :Among the different methodologies for the preparation of polymer-modified electrode, electropolymerization has been demonstrated as a very convenient method to immobilize polymer on the electrode surface because the thickness, permeation and charge transport characteristics of the modified polymeric film can be well defined by the controlled electrochemical parameters [15]. 5-Hydroxytryptamine (serotonin, 5-HT) is an important and major biogenic monoamine neurotransmitter as well as neuromodulator [16],widely distributed in human brain and makes an important contribution in wide variety of biological, physical, psychopathological processes including sleep regulation, depression, eating disorder, alcoholism, infantile autism, anxiety disorders, muscle contraction, liver regeneration, endocrine regulation, obsessive-compulsive disorder and psychosis [17–20]. Serotonin was found in gastrointestinal (GI) tract, platelets, and in central nervous system (CNS).
Reduction in spinal-induced hypotension with ondansetron in parturients undergoing caesarean section: A double-blind randomised, placebo-controlled study
2012, International Journal of Obstetric AnesthesiaOndansetron Given Intravenously Attenuates Arterial Blood Pressure Drop Due to Spinal Anesthesia: A Double-Blind, Placebo-Controlled Study
2008, Regional Anesthesia and Pain MedicineHalothane induces vesicular and carrier-mediated release of [<sup>3</sup>H]serotonin from rat brain cortical slices
2008, Neurochemistry International
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