Original contributionEnhanced resistance to oxidation of low density lipoproteins and decreased lipid peroxide formation during β-carotene supplementation in cystic fibrosis
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Cited by (96)
Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: A systematic review and meta-analysis
2020, Redox BiologyCitation Excerpt :Eleven studies were eligible and studied the levels of lipid peroxidation within the plasma or serum of people with CF versus non-CF controls. The biomarkers studied were MDA (inclusive of the thiobarbitoric acid reactive substances [TBARS] assay) (n = 7) [7,42,54,56,58,61,64,72,74], hydroperoxides (n = 3) [43,64,72] and total 8-iso-PGF2α (n = 3) [41,58,75]. The concentration of MDA (SMD 1.33, 95% CI 0.43 to 2.24, p < 0.01, I2 96%, 8 trials; Fig. 3) [7,54,56,58,61,64,72,74] and total 8-iso-PGF2α (SMD 0.64, 95% CI 0.23 to 1.05, p < 0.01, I2 0%, 2 trials; Fig. 3) [58,75] in the plasma or serum were significantly higher in people with clinically-stable CF compared to the non-CF controls (Fig. 3).
Low-density lipoprotein oxidation biomarkers in human health and disease and effects of bioactive compounds
2017, Free Radical Biology and MedicineNutritional Strategies to Modulate Inflammation and Oxidative Stress in Patients with Cystic Fibrosis
2015, Diet and Exercise in Cystic FibrosisInflammation, oxidative stress, and cardiovascular disease risk factors in adults with cystic fibrosis
2014, Free Radical Biology and MedicineCitation Excerpt :Numerous other clinical conditions remain uncertain as to their potential contribution to atherosclerotic CVD risk factors in patients with CF, partly due to their controversy within the general population. These clinical conditions include issues related to reduced coenzyme Q10 levels in patients with CF [306] and often reduced levels of carotenoids, vitamin E, and vitamin D, all of which have even been touted as factors influencing the incidence and/or severity of atherosclerotic CVD [159,307–310]. Such factors as the “anti-inflammatory” agents NSAIDS, glucosteroids, and azithromycin have been touted as presenting an increased risk of CVD in the general population [297,311] but are frequently prescribed to patients with CF. Finally, elevated homocysteine levels have been found in children with CF [312] and could represent another factor influencing CVD incidence [313].
Oxidative stress and antioxidant therapy in cystic fibrosis
2012, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :The tolerable upper intake level (UL) and the Acceptable Daily Intake (ADI), established by the Joint FAO/WHO Expert Committee on Food Additives for the natural form of vitamin E as α-tocopherol equivalents are of 300 mg/die and 0.15–2.0 mg/kg body weight/die, respectively [172,177]. Levels of plasma carotenoids such as β-carotene, β-cryptoxanthin, and total lycopene are significantly lowered in CF patients and this was associated with higher susceptibility to lipid peroxidation [5,178–180]. Rust et al. [178] demonstrated that the long-term oral supplementation with 50 mg β-carotene/day (i.e. 1 mg β-carotene/kg BW/day) restored the levels of this carotenoid, while sub-optimal supplementation was observed at doses of 10 mg β-carotene/day or lower, thus confirming the need of high doses of this fat-soluble factor to overcome the limited absorption and thus to achieve plasma concentrations of healthy control subjects.
Effect of an antioxidant-rich multivitamin supplement in cystic fibrosis
2011, Journal of Cystic Fibrosis