Oxygen radicals in lung pathology

doi:10.1016/0891-5849(90)90015-B

Free Radical Biology and Medicine

Volume 9, Issue 5, 1990, Pages 381-400

https://doi.org/10.1016/0891-5849(90)90015-B Get rights and content

Abstract

Pulmonary tissue can be damaged in different ways, for instance by xenobiotics (paraquat, butylated hydroxytoluene, bleomycin), during inflammation, ischemia reperfusion, or exposure to mineral dust of to normobaric pure oxygen levels. Reactive oxygen species are partly responsible for the observed pulmonary tissue damage. Several mechanisms leading to toxicity are described in this review. The reactive oxygen species induced bronchoconstriction, elevate mucus secretion, and cause microvascular leakage, which leads to edema formation. Reactive oxygen species even induced an autonomic imbalance between muscarinic receptor-mediated contraction and the β-adrenergic-mediated relaxation of the pulmonary smooth muscle. Vitamin E and selenium have a regulatory role in this balance between these two receptor responses. The autonomic imbalance might be involved in the development of bronchial hyperresponsiveness, occuring in lung inflammation. Finally, several antioxidants are discussed which may be beneficial as therapeutics in several lung diseases.

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¹: Cees J. A. Doelman (1963), graduated (1988) in Pharmacochemistry at the Vrije Universiteit in Amsterdam, is now of doctoral-student at the department of of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit Amsterdam, The Netherlands. His research involves investigations on the role of oxygen radicals in the ashtmatic lung pathology, and is entirely subsidized by the Dutch Asthma Foundation.

²: Aalt Bast (1953) received his Ph.D. at the Faculty of Pharmacy at the state University of Utrecht (The Netherlands). He is currently professor at the Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands. His research interests involve the role of radical processes in the biotransformation of xenobiotics, in the etiology of intestinal ischemia, heart ischemia, and lung damage. Moreover, the molecular pharmacology of histamine forms an important research subject.

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Original contributionOxygen radicals in lung pathology

Abstract

J. Allergy Clin. Immunol.

Lancet

Free Radic. Biol. Med.

Free Radic. Biol. Med.

FEBS Lett.

J. Biol. Chem.

J. Allergy Clin. Immunol.

Chest

Trends in Pharmacol. Sc.

J. Biol. Chem.

Biochim. Biophys. Res. Commun.

Toxic. in Vitro

Envrion. Res.

Arch. Biochem. Biophys.

Tox. Appl. Pharmacol.

Biochem. Pharmacol.

Biochem. Biophys. Acta

J. Biol. Chem.

Tox. Appl. Pharmacol.

Tox. Appl. Pharmacol.

Biochem. Pharmacol.

Biochem. Pharmacol.

Pharmac. Ther.

Tox. Appl. Pharmacol.

Biochem. Pharmacol.

Tox. Appl. Pharmacol.

Tox. Appl. Pharmacol.

Tox. Appl. Pharmacol.

Tox. Appl. Pharmacol.

Chest

Am. J. Med.

Airway hyperresponsiveness and inflammation

Br. Med. Bull.

Asthma: 1. Pathophysiologic features and evaluation of severity

Can. Med. Assoc. J.

Allergen-induced increase in non-allergic bronchial reactivity

Clin. Allergy

A clinical and pathological study of fatal cases of status asthmaticus

Thorax

Morphological integrity of the bronchial epithelium in mild asthma

Thorax

Role of inflammation in the hyperreactivity of the airways in asthma

Thorax

The eosinophil and the pathopsiology of asthma

J. Allergy Clin. Immunol.

Inflammatory mediators and asthma

Pharmacol. Rev.

Lung exposure to mineral dusts enhances the capacity of lung inflammatory cells to release superoxide anions

J. Leukocyte Biol.

Biochemical mechanisms involved in the priming of neutrophils by tumor necrosis factor

J. Leukocyte Biol.

Selective priming of rate and duration of the respiratory burst of neutrophils by 1,2-diacyl and 1-allkyl-2-acyl diglycerides

J. Biol. Chem.

The respiratory burst of phagocytes

Free radicals in medicine. I. Chemical nature and biological reactions

Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes

J. Clin. Invest.

The respiratory burst and mechanims of oxygen radical-mediated tissue injury

The respiratory burst of phagocytes

J. Clin. Invest.

Macrophages and polymorphonuclear neutrophils in lung defence and injury. State of the art

Am. Rev. Respir. Dis.

Absence of circulating products of oxygen-derived free radicals in acute severe asthma

Eur. Respir. J.

Phagocytosis induction anion release from activated huma alveolar macrophages in asthma

J. Bioluminescence and Chemoluminescence

Original contribution
Oxygen radicals in lung pathology