Sub-clinical worsening of bronchial asthma during estrogen replacement therapy in asthmatic post-menopausal women
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Cited by (51)
Estrogen replacement therapy and asthma
2013, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :The authors also found that the age-adjusted increased relative risk for asthma was positively dose-related (p for trend = 0.007) [72]. This finding is in accordance with the results of an other contemporary study showing a reduction in the measured peak expiratory flow and an increased consumption of bronchodilators by inhalation in 15 postmenopausal women during ERT [80]. The potential detrimental effects of ERT on asthma in menopausal and postmenopausal women has been reported in a series of successive studies.
Animal models of airway inflammation and airway smooth muscle remodelling in asthma
2009, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :In the earliest reports documenting premenstrual asthma, it was hypothesized that a high level of estrogen may play a role in the aetiology of the syndrome [95,98], and it was even once referred to as “endocrine allergy” [99]. Although it is quite possible that female sex hormones are responsible for the observed premenstrual asthma symptoms, clinical studies that correlate asthma with the use of oral contraceptives or hormone replacement therapy show conflicting and inconclusive data on the role of estrogen and progesterone [100–110]. Small rodent models may provide clues toward specific mechanistic pathways that might confound inflammation and remodelling of the airways in asthmatic women.
Role of estradiol metabolism in asthma
2009, Bioscience HypothesesCitation Excerpt :Furthermore, obese women, who have increased E2 plasma levels, are at a higher risk for asthma and have elevated atopy [4–6] and “premenstrual asthma” is a well-recognized clinical entity [7,8]. Also, use of estrogens exacerbates the disease in asthmatic postmenopausal women [9] and increases the rate of newly diagnosed asthma [10]. Yet, strong evidence regarding clear beneficial or adverse effects of E2 in asthma is lacking.