Original studyAcute hemodynamic response to the S2-serotonergic receptor antagonist, ketanserin, in patients with primary pulmonary hypertension
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Cited by (19)
Targeting the serotonin pathway for the treatment of pulmonary arterial hypertension
2013, Pharmacology and TherapeuticsCitation Excerpt :Of the 5-HT receptors, 5-HTR2A is dominantly expressed in vasculature, yet shows differential expression in pulmonary vessels or increase in PAH (Marcos et al., 2005). Early studies to assess Ketanserin efficacy as a 5HTR2A antagonist proved clinically effective in the treatment of systemic hypertension, yet could not be used in PAH due to the adverse effects of decreased systemic pressure (Mcgoon & Vlietstra, 1987; Frishman et al., 1995). A selective 5HTR2B antagonist (PRX-8066) was assessed in a two week randomized, double-blind Phase IIa trial in 72 patients with PAH associated with COPD.
Serotonin and pulmonary hypertension-from bench to bedside?
2009, Current Opinion in PharmacologyThe role of 5-hydroxytryptamine in the control of pulmonary vascular tone in a rabbit model of pulmonary hypertension secondary to left ventricular dysfunction
2005, Pulmonary Pharmacology and TherapeuticsObesity drugs and the heart
1999, Current Problems in CardiologyUse of ketanserin in the treatment of hypertension following coronary artery surgery
1994, Journal of Cardiothoracic and Vascular Anesthesia
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Supported in part by American College of Cardiology/Merck-Sharp-Dohme Fellowship, 1982–83.
Copyright © 1987 Published by Elsevier Ireland Ltd.