ORIGINAL ARTICLESEarly versus delayed neonatal administration of a synthetic surfactant — the judgment of OSIRIS☆
References (17)
- et al.
Randomized placebo-controlled trial of human surfactant given at birth versus rescue administration in very low birth weight infants with lung immaturity
J Pediatr
(1991) - et al.
Effects of two rescue doses of a synthetic surfactant on mortality rate and survival without bronchopulmonary dysplasia in 700- to 1350-gram infants with respiratory distress syndrome
J Pediatr
(1991) - et al.
Respiratory distress syndrome
Other acute lung disorders
- et al.
The arterial/alveolar oxygen tension ratio: an index of gas exchange applicable to varying inspired oxygen concentrations
Am Rev Resp Dis
(1974) - et al.
Classifying perinatal death: fetal and neonatal factors
Br J Obstet Gynaecol
(1986) Prophylactic surfactant vs treatment with surfactant
- et al.
A comparison of surfactant as immediate prophylaxis and as rescue therapy in newborns of less than 30 weeks' gestation
N Engl J Med
(1991)
Cited by (228)
Pharmacologic Therapies I: Surfactant Therapy
2017, Assisted Ventilation of the Neonate: An Evidence-Based Approach to Newborn Respiratory Care: Sixth EditionDesign and conduct of a large obstetric or neonatal randomized controlled trial
2015, Seminars in Fetal and Neonatal MedicineCitation Excerpt :Researchers should explain who was blinded and how. However, blinding is often not feasible, e.g. in trials of obstetric management [17,18,71,85], neonatal surfactant [114,115] or respiratory support [113,116,117]. Lack of blinding can lead to bias, but double blinding is not a prerequisite for high quality.
Defining neonatal hypoglycaemia: A continuing debate
2014, Seminars in Fetal and Neonatal MedicineCitation Excerpt :However, subsequent studies using the same approach failed to support this finding [12,22,23]. Mindful of the need to confirm the findings by Lucas et al. [19], a group of clinicians and nurses in the north of England (the Northern Neonatal Nursing Initiative Trial Group) initiated an observational study along with two other randomised trials [24,25]; all nested into the prospective study of early neonatal care and neurodevelopmental outcome in preterm infants. This prospective study included all 781 babies of <32 weeks of gestation, born in 1990 and 1991 to mothers residing in the north of England, and all the surviving babies had their blood glucose levels measured (by glucose oxidase assay) every morning at a fixed time in the first 10 days of life.
Surfactant Replacement: Present and Future Present and Future
2012, The Newborn Lung: Neonatology Questions and Controversies Expert ConsultSurfactant Replacement. Present and Future.
2012, The Newborn LungCONSORT 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials
2012, International Journal of SurgeryCitation Excerpt :Example—“The risk of oxygen dependence or death was reduced by 16% (95% CI 25%–7%). The absolute difference was −6.3% (95% CI −9.9% to −2.7%); early administration to an estimated 16 babies would therefore prevent 1 baby dying or being long-term dependent on oxygen” (also see Table 7).242 Explanation—When the primary outcome is binary, both the relative effect (risk ratio (relative risk) or odds ratio) and the absolute effect (risk difference) should be reported (with confidence intervals), as neither the relative measure nor the absolute measure alone gives a complete picture of the effect and its implications.
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Correspondence to Perinatal Trials Service, National Perinatal Epidemiology Unit, Radcliffe Infirmary, Oxford OX2 6HE, UK