Effect of interleukin-1β on airway hyperresponsiveness and inflammation in sensitized and nonsensitized Brown-Norway rats☆
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Cited by (63)
Regulation of hypothalamic-pituitary-adrenal axis activity and immunologic function contributed to the anti-inflammatory effect of acupuncture in the OVA-induced murine asthma model
2017, Neuroscience LettersCitation Excerpt :In line with previous research results, we have shown that acupuncture reduced TNF-α level in serum. IL-1β is an important inducer of the pathological progression of allergic asthma [18], and IL-1β has been shown to significantly increase AHR, bradykinin and neutrophil counts in the BALF in OVA-sensitized rats [19]. Inhalation of anti-IL-1β IgY inhibits pathological responses in the pulmonary tissues of guinea pigs with allergic asthma [18].
The Immunobiology of Asthma
2016, Encyclopedia of ImmunobiologyIdentification of novel immune phenotypes for allergic and nonallergic childhood asthma
2015, Journal of Allergy and Clinical ImmunologyCitation Excerpt :In our study in vitro–stimulated PBMCs of patients with NA were characterized by increased levels of IL-1β, which plays a central role in antimicrobial host defense and was associated with autoinflammatory diseases. Consistent with animal models, in which IL-1β was associated with airway hyperresponsiveness and augmented neutrophil counts,26 both IL-1β levels and neutrophil counts were increased in our study. In addition to activating neutrophils, IL-1β was shown to induce a TH17 bias in adaptive immune responses by regulating TH17 differentiation, expansion, and maintenance.27
Therapeutic potential of anti-IL-1β IgY in guinea pigs with allergic asthma induced by ovalbumin
2014, Molecular ImmunologyCitation Excerpt :Mature IL-1β creates a proinflammatory milieu that produces airway inflammatory responses (Besnard et al., 2012; Lappalainen et al., 2005). In OVA-sensitized rats, the intratracheal administration of IL-1β has been shown to significantly increase AHR, bradykinin and neutrophil counts in the BALF (Tsukagoshi et al., 1994). However, Li et al. demonstrated that the asthmatic symptoms in guinea pigs were obviously attenuated after administration of rhIL-1ra solution via ultrasonic spraying (Li et al., 2006).
MAPK/NF-κB-dependent upregulation of kinin receptors mediates airway hyperreactivity: A new perspective for the treatment
2013, Pharmacological ResearchCitation Excerpt :Inhalation of TNF-α increases AHR to methacholine in both normal and asthmatic subjects [67]. IL-1β treatment induces airway inflammation and AHR to bradykinin in sensitized and non-sensitized rats [68] as well as in human bronchial preparations [69]. Although both TNF-α [70] and IL-1β [8] increase airway smooth muscle contractile response to kinin B1 and B2 receptor agonists, IL-1β effects are showed to act through increase in TNF-α production [8] and/or enhanced TNF receptor expression [71], suggesting that TNF-α plays a central role in the development of AHR and airway inflammation.
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Supported by Medical Research Council (UK) Programme Grant.