Original articleTryptase and histamine as markers to evaluate mast cell activation during the responses to nasal challenge with allergen, cold, dry air, and hyperosmolar solutions☆,☆☆
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Human C1q Tumor Necrosis Factor 8 (CTRP8) defines a novel tryptase+ mast cell subpopulation in the prostate cancer microenvironment
2023, Biochimica et Biophysica Acta - Molecular Basis of DiseaseImmunological response to bacterial infection in a pelagic tunicate: Inflammation in the salp Thalia democratica
2018, Journal of Invertebrate PathologyCitation Excerpt :It is unclear whether these cells are able to restore their morphology once degranulation is completed or whether they undergo an irreversible degradation, as the hyaline amebocytes do. Histamine can be detected immunohistochemically as a ‘mast cell-degranulation marker’ after an immune stimulus in vertebrates (Proud et al., 1992; Hogan and Schwartz, 1997) and in tunicates (García-García et al., 2014). Even in vertebrates, mast cell degranulation can be activated not only through immunoglobulin E/antigen but also by a glycoprotein-mediated interaction of polycationic peptides with G protein α subunit (Gomes et al., 1994; Lorenz et al., 1998).
Biology of Mast Cells and Their Mediators
2014, Middleton's Allergy: Principles and Practice: Eighth EditionHistamine reduces GPIbα-mediated adhesion of platelets to TNF-α-activated vascular endothelium
2013, Thrombosis ResearchDifferential Diagnosis in Allergy
2011, Otolaryngologic Clinics of North AmericaCitation Excerpt :Facial pressure, headaches, and rhinorrhea are common nasal complaints in patients who are exposed to extreme changes in barometric pressures (ie, aviation workers and mountain climbers). Mast cell degranulation and stimulation of irritated nerve endings are felt to be the offending mechanism's pathophysiology.61,62 Gustatory rhinitis occurs when a patient ingests a certain food, usually hot or spicy: mucoid or watery rhinorrhea ensues.41,63,64
Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge
2010, Journal of Allergy and Clinical ImmunologyCitation Excerpt :Hanf et al14 demonstrated a 90% reduction in nasal symptoms scores to allergen challenge (variety of allergens) after 16 weeks of omalizumab treatment. Similar to Hanf et al,14 we were not able to measure a consistent rise in nasal lavage histamine or tryptase content (data not shown) after NAC, unlike others.10 In summary, these findings support the importance of the basophil either directly being involved in the acute response to allergen during NAC or as a biomarker of the end-organ nasal clinical allergic responses.
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Supported in part by National Institutes of Health Grants HL 32272, HL 37119, AI 31335, and AI 08270.
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Publication No. 073 from The Johns Hopkins Asthma and Allergy Center, Baltimore, Md.
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Current address: Department of Chemistry, University of Essex, Wivenhoe Park, Colchester, C04 3SQ, England.