Original articleCorrelation of bronchial eosinophil and mast cell activation with bronchial hyperresponsiveness in children with asthma☆
References (29)
New concepts in the pathogenesis of bronchial hyperresponsiveness and asthma
J Allergy Clin Immunol
(1989)Asthma and inflammation
J Allergy Clin Immunol
(1991)- et al.
Bronchial hyper-responsiveness in asthmatic children: correlation with macrophages and eosinophils in broncholavage fluid
Chest
(1989) - et al.
Difference in mediator release between allergic rhinitis and asthma
J Allergy Clin Immunol
(1991) - et al.
Blood eosinophils and eosinophil derived proteins in allergic asthma
J Allergy Clin Immunol
(1989) - et al.
Release of granule proteins by eosinophils from allergic and nonallergic patients with eosinophilia on immunoglobulin-dependent activation
J Allergy Clin Immunol
(1991) The eosinophil and bronchial asthma: current understanding
J Allergy Clin Immunol
(1990)One explanation of the asthma paradox: inhibition of natural anti-inflammatory mechanism by β2-agenists
Lancet
(1991)- et al.
Airway hyper-responsiveness and asthma
A new approach to the treatment of asthma
N Engl J Med
(1989)
Eosinophilic inflammation in asthma
N Engl J Med
Dust-free bedrooms in the treatment of asthmatic children with house dust or house dust mite allergy: a controlled trial
Pediatrics
Introduction to statistical analysis
Airway response to inhaled bronchoconstrictor drugs: clinical measurement and standardization
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2016, Journal of Allergy and Clinical Immunology: In PracticeCitation Excerpt :Some studies have found that younger preschool-aged children have a predominance of neutrophilic airway inflammation,23,24 whereas others have demonstrated eosinophilic airway inflammation in those with confirmed recurrent wheezing.25-27 It is not clear at which age the presumed transition from neutrophilic to eosinophilic airway inflammation seen in school-aged children28-30 occurs due to the paucity of airways studies in this vulnerable population. Furthermore, multiple studies have demonstrated that the use of inhaled corticosteroids (ICSs) in preschool-aged children with recurrent wheezing has resulted in reducing wheezing exacerbations compared with placebo31-34 and ICSs have been recommended by asthma guidelines, particularly in those with a history of severe wheezing exacerbations or those with a positive mAPI.35,36
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Supported by grants from the B.C. Lung Association and Sandoz Canada, Inc.