Original articleLeukotrienes, LTC4 and LTB4, in bronchoalveolar lavage in bronchial asthma and other respiratory diseases☆
References (26)
- et al.
New perspectives on the putative role of eicosanoids in airway hyperresponsiveness
J Allergy Clin Immunol
(1985) - et al.
Local effects of synthetic leukotrienes LTC4, LTD4, LTF4, and LTB4 in human skin
J Invest Dermatol
(1983) - et al.
Bronchoconstriction produced in man by leukotrienes C and D
Lancet
(1981) - et al.
Measurement of immunoreactive leukotriene C4 in blood of asthmatic children
Biochem Biophys Res Commun
(1985) - et al.
Incorporation of radiolabel from [1- 14C]5-hydroperoxy-eicosatetraenoic acid into slow-reacting substance
Biochem Biophys Res Commun
(1980) - et al.
Inhibition of leukotriene C4 and B4 generation by human eosinophils and neutrophils with the lipoxygenase pathway inhibitors U-60257 and BW755C
Int J Immunopharmacol
(1985) - et al.
Release of leukotrienes in patients with bronchial asthma
J Allergy Clin Immunol
(1988) - et al.
Identification of leukotrienes D and B in sputa from cystic fibrosis patients
Lancet
(1981) Leukotrienes: mediators of immediate hypersensitivity
Science
(1983)Eicosanoids and lung inflammation
Am Rev Respir Dis
(1987)
Slow-reacting substance leukotrienes contract human airway and pulmonary vascular smooth muscle in vitro
Nature
Slow-reacting substances, leukotriene C4 and D4, increase the release of mucus from human airways in vitro
Am Rev Respir Dis
Complement-receptor enhancement and chemotaxis of human neutrophils and eosinophils by leukotrienes and other lipoxygenase product
Clin Exp Immunol
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2020, European Journal of Medicinal ChemistryCitation Excerpt :Moreover, LTB4 can induce the release of elastase from neutrophil, facilitating the accumulation of LTB4 and leading to the formation of a pro-inflammatory positive cycle [10]. Consistent with basic research, clinical studies revealed that the overly elevated levels of the LTB4 have been evidenced in the broncho alveolar lavage fluid (BALF) and lung tissues of IPF cases [11,12]. In addition, LTB4 levels were elevated in bleomycin (BLM)-injured rats, and specific antagonist of LTB4 receptor BLT1 or BLT1 deficiency could mitigate BLM-induced pulmonary fibrosis [13–15].
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2018, Clinical ImmunologyImportance of the leukotriene B4-BLT1 and LTB4-BLT2 pathways in asthma
2017, Seminars in ImmunologyThe efficacy of single-high dose inhaled corticosteroid versus oral prednisone treatment on exhaled leukotriene and 8-isoprostane levels in mild to moderate asthmatic children with asthma exacerbation
2016, Allergologia et ImmunopathologiaCitation Excerpt :Cysteinyl leukotrienes (Cys-LTs) are potent constrictors and pro-inflammatory mediators.8,9 Higher levels of Cys-LTs have been found in bronchoalveolar lavage (BAL), induced sputum, and in exhaled breath condensate (EBC) of asthmatics, especially in patients with unstable asthma.8–12 In addition, it has been suggested that Cys-LTs play an important role in airway remodelling.
- ☆
Supported by the Wellcome Trust (U.K.) and the Clinical Research Committee of the National Heart and Chest Hospitals, London, England.
- 1
From the Department of Allergy and Clinical Immunology, Cardiothoracic Institute, London, England.
- ∗
From the Brompton Hospital, London, England.