Late asthmatic responses induced by ragweed pollen allergen☆,☆☆
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Cited by (179)
Frederick E. "freddy" Hargreave, MB ChB, MD
2016, Annals of Allergy, Asthma and ImmunologyCitation Excerpt :Freddy was meticulous in his research methods (and subsequent manuscript writing). Methods originating in his laboratory, including those for histamine and methacholine brochoprovocation,2–4 allergen bronchoprovocation,5,6 and noninvasive assessment of sputum inflammatory cells,7,8 have become the gold standards. Studies of interactions of these tests yielded important new information.
Correlation between CCL26 production by human bronchial epithelial cells and airway eosinophils: Involvement in patients with severe eosinophilic asthma
2015, Journal of Allergy and Clinical ImmunologyInhaled allergen bronchoprovocation tests
2013, Journal of Allergy and Clinical ImmunologyCitation Excerpt :The selection of the starting concentration for the initial allergen challenge, which is frequently referred to as a screening challenge, is based on safety. In the past, investigators have used the weakest of the available allergen concentrations producing a discernible (2-3 mm) wheal on skin prick testing as the starting concentration.26 Although this is safe, it creates the potential for a long challenge procedure.
Allergens
2009, Asthma and COPDAllergens
2008, Asthma and COPD: Basic Mechanisms and Clinical ManagementT-cell mediated late increase in bronchial tone after allergen provocation in a murine asthma model
2008, Clinical ImmunologyCitation Excerpt :A central role of T cells is however not generally accepted [4]. In about 50% of patients, allergen-induced airway obstruction recurs after several hours to reach a maximum over 6 to 12 h (the late phase asthmatic response, LPAR), resolving within 24 h [5,6]. In the context of the LPAR, the exact link between inflammation and symptoms of obstruction remains obscure [7], the relative roles of different cell types and mediators are still unclear, although T cells most likely are primarily responsible [8].
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Assisted by the Ontario Thoracic Society, Ontario Department of Health (PR 220) and the Medical Research Council of Canada (MA 3404).
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Presented in part at the Twenty-ninth Annual Meeting of the American Academy of Allergy, Feb. 13, 1973.
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Fellow of the Medical Research Council of Canada.
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Recipient of a Queen Elizabeth II Scientist Award.