Multielemental assay of tissues of deceased smelter workers and controls
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2019, Environmental ResearchCitation Excerpt :In addition, a systematic review suggested mixed evidence of sex-specific effects of arsenic exposure on respiratory health (Sanchez et al., 2016). Previous animal and human studies have indicated that arsenic can accumulate in the lungs and induce inflammation (Bertolero et al., 1981; De et al., 2004; Gerhardsson et al., 1988), which may further lead to the development of respiratory symptoms or diseases. Moreover, arsenic exposure is linked to elevated levels of matrix metalloproteinase-9, a biomarker that can regulate pathological remodeling processes involving inflammation (Atkinson and Senior, 2003; Boitano et al., 2008; Olsen et al., 2008).
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2017, Environment InternationalCitation Excerpt :However, a variety of studies supported the biological plausibility of arsenic-induced lung function impairment. In animal and human studies, arsenic has been found to be accumulated in the lungs more than any other organs, except for the kidneys and liver (Bertolero et al., 1981; Gerhardsson et al., 1988; Kenyon et al., 2008; Saady et al., 1989; Vahter et al., 1984). This accumulated arsenic could cause damage in lung tissue by inducing inflammation (De et al., 2004), increasing pulmonary fibrosis (Nemery, 1990; von Ehrenstein et al., 2005), and inducing oxidative stress (Hays et al., 2006; Lantz and Hays, 2006).
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