Original contributionMorphogenesis of abnormal elastic fibers in lungs of patients with panacinar and centriacinar emphysema
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2022, Archivos de BronconeumologiaExtracellular matrix in lung development, homeostasis and disease
2018, Matrix BiologyCitation Excerpt :Cross-sectional studies albeit with small sample sizes consistently show an increase in collagen content and altered fibril morphology in lungs of patients with moderate and severe COPD [112–114]. Abnormal elastin fibers (fragmented, clumped) with variable changes in elastin content are evident in emphysematous lungs [112,113,115,116]. Animal models of emphysema, typically involving airway elastase instillation or chronic cigarette smoke exposure, also demonstrate increased collagen and elastin synthesis with matrix deposition during the establishment and progression of the airspace lesion [117–121].
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2015, Medical HypothesesA cytokine axis regulates elastin formation and degradation
2013, Matrix BiologyCitation Excerpt :Steady state, basal levels of elastin expression and breakdown remain low in adult tissues as well as in cells isolated from adult tissues (Starcher, 1986; Parks et al., 1988). Elastin expression is reactivated in diseases such as pulmonary hypertension, dermal elastosis, pseudoxanthoma elasticum, Buschke–Ollendorff syndrome, Moyamoya disease, cigarette smoke-induced emphysema, severe chronic obstructive pulmonary disease (COPD) and forms of progeria (Holbrook and Byers, 1982; Sephel et al., 1988; Botney et al., 1992; Bernstein et al., 1994; Stenmark et al., 1994; Yamamoto et al., 1997; Hoff et al., 1999; Deslee et al., 2009; Rangasamy et al., 2009), although in many of these disorders the elastin produced is disorganized and dysfunctional (Kuhn et al., 1976; Fukuda et al., 1989; Hoff et al., 1999). Much is known about the molecular mechanisms underlying elastin formation in development and disease.
Pulmonary fibroblasts from COPD patients show an impaired response of elastin synthesis to TGF-β1
2011, Respiratory Physiology and NeurobiologyCitation Excerpt :Several experimental studies have reported that elastin synthesis is increased in emphysematous lungs in animal models (Chambers and Laurent, 1996). Similarly, investigations on human emphysematous lungs report increased synthesis of elastin (Fukuda et al., 1989). In a recent study, Deslee et al. (2009) reported that elastin mRNA expression was significantly increased in the alveolar walls in very severe COPD compared to donors, non-COPD and stages 2–3 COPD), but elastic fibre content was not increased per lung volume.