Impulse activity in afferent vagal C-fibres with endings in the intrapulmonary airways of dogs☆
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2023, Regulatory Toxicology and PharmacologyNeurokinin 1 and 2 receptors are involved in PGE<inf>2</inf>- and citric acid-induced cough and ventilatory responses
2022, Respiratory Physiology and NeurobiologyCitation Excerpt :Exposure to aerosolized citric acid (CA) or capsaicin (CAP) provokes individual loud coughs (Type I), while prostaglandin E2 (PGE2) induces bouts of smaller coughing with a weak coughing sound (Type II). Type I and II coughs are evoked primarily by stimulation of transient receptor potential cation channel subfamily V member 1 (TRPV1) and EP3 (a PGE2 receptor) of bronchopulmonary C-fibers (PCFs) respectively (Coleridge and Coleridge, 1977; Forsberg et al., 1988; Gao et al., 2021; Lalloo et al., 1995; Satoh et al., 1993). PCFs contain tachykinin neuropeptides, including substance P (SP) and neurokinin A (NKA) (Lee et al., 2013; Lundberg et al., 1984).
Regulation of breathing by cardiopulmonary afferents <sup>☆</sup>
2022, Handbook of Clinical NeurologyAbraham Guz memorial: Still unresolved hypotheses: Lung reflexes and perceptions of breathing
2015, Respiratory Physiology and NeurobiologyCitation Excerpt :Those in the larger bronchi are more chemosensitive; they may cause cough, but also stimulate hyperventilation, augmented breaths (as in Head’s paradoxical reflex), mucus secretion, bronchoconstriction and laryngeal closure. The third group of vagal lung afferents to be considered are the J (juxtacapillary) receptors which transmit impulses through the unmyelinated, slowly conducting C fibres of the afferent vagus (Paintal, 1953; Coleridge and Coleridge, 1977, 1984). Why juxtacapillary?
Peripheral neural circuitry in cough
2015, Current Opinion in PharmacologyCitation Excerpt :C fibers terminate in unstructured endings throughout the mucosa and submucosa of the airways [2,23,40]. C fibers are polymodal sensors of noxious stimuli [18,41–43], due to their characteristic expression of specific receptors for noxious stimuli. The hallmark of C fiber nociceptive afferents is sensitivity to capsaicin due to the expression of TRPV1 in nociceptors [44].
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This work was supported by U.S. Public Health Service Grants HL-13875 and HL-06285 from the National Heart and Lung Institute.