Short communicationBronchial ciliogenesis and oral steroid treatment in patients with asthma
References (11)
Scanning electron microscopic studies of bronchial mucosa before and during treatment with beclomethasone dipropionate inhalations
Scand J Resp Dis Suppl
(1977)- et al.
Fiberoptic bronchoscopy including bronchial biopsies in asthmatics after long-term high dose budesonide aerosol
Prog Resp Res
(1985) - et al.
Damage of the airway epithelium and bronchial reactivity in patients with asthma
Am Rev Resp Dis
(1985) - et al.
Ultrastructure of the bronchial epithelium in three children with asthma
Pediat Pulmonol
(1985) Reconstruction of centriole formation and ciliogenesis in mammalian lungs
J Cell Sci
(1968)
Cited by (12)
Glucocorticoid actions on airway epithelial responses in immunity: Functional outcomes and molecular targets
2007, Journal of Allergy and Clinical ImmunologyCitation Excerpt :An increase in the number of ciliated cells, with restoration of the ciliated/goblet cell ratio, was documented by electron microscopy after a 3-month treatment with ICSs in newly diagnosed patients with asthma,39 and epithelial cells in sputum decreased after glucocorticoid treatment.40 In a small study, glucocorticoid treatment had a positive effect on ciliogenesis.41 However, only a partial reduction of epithelial damage was seen after 10 years of daily ICS treatment in patients with severe asthma.42
Airway inflammation as an assessment of chronic nonproductive cough
2001, ChestCitation Excerpt :Epithelial damage along with inflammatory cell infiltration have been observed in patients with chronic cough. This is supported by studies789 showing that steroids assist in healing the damaged epithelial cells by suppressing the infiltration of inflammatory cells, and that they also participate in regenerating the destroyed cilia, which results in a reduction of coughing. Therefore, the pathogenesis of chronic cough can be summarized as the damage of epithelial cells due to airway inflammation.
The effect of inflammation on mucociliary clearance asthma: An overview
2000, ChestCitation Excerpt :It is also a characteristic pathologic featureof asthmatic tissue obtained from autopsy,17 bronchialbiopsy50 and BAL.51 In this regard, ciliatedcells obtained in bronchial biopsy52 and in BAL53 correlate with the degree of bronchialresponsiveness, and ciliary destruction is more evident with persistentdisease, although it can be reversed with steroidtreatment.54 Structural changes, such as ciliary epithelial lesions, with cells thatoften appear swollen, as well as intercellular space edema have beendescribed in the airway epithelium of asthmatic patients
Asthma
2022, Exercise Management for Referred Medical Conditions