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Maternal Pre-Pregnancy Obesity and Diagnosis of Asthma in Offspring at Age 3 Years

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Abstract

Objective The objective of this study was to examine the relationship between maternal pre-pregnancy obesity and a diagnosis of asthma in offspring at age 3 years. Methods A population-based sample of children born in large U.S. cities in 1998–2000 was followed since birth (N = 1971). The main outcome measure was whether the mother reported at 3 years that the child had ever been diagnosed with asthma. Multilevel logistic regression models were used to estimate the association between maternal pre-pregnancy obesity and child asthma diagnosis, as well as the extent to which the association can be explained by sociodemographic, medical, obstetric, and behavioral factors associated with both conditions. Results Children with obese mothers had 52% higher odds of having an asthma diagnosis by age 3 (OR = 1.52; 95% CI: 1.18–1.93). Sociodemographic, medical, obstetric, and behavioral factors explained some, but not all, of the association. Conclusions Maternal pre-pregnancy obesity is associated with diagnosis of asthma in offspring at age 3 years. The results from this study are preliminary and need to be replicated and further explored, but are suggestive of a complex intergenerational linkage between obesity and asthma.

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References

  1. U.S. Department of Health and Human Services. (2000). Action against asthma: A strategic plan for the Department of Health and Human Services.

  2. Akinbami, L. J., & Schoendorf, K. C. (2002). Trends in childhood asthma: Prevalence, health care utilization, and mortality. Pediatrics, 110, 315–322.

    Article  PubMed  Google Scholar 

  3. Aligne, A. C., Auinger, P., Byrd, R. S., & Weitzman, M. (2000). Risk factors for pediatric asthma: Contributions of poverty, race, and urban residence. American Journal of Respiratory and Critical Care Medicine, 162, 873–877.

    PubMed  CAS  Google Scholar 

  4. Weiss, K. B., Gergen, P. J., & Crain, E. F. (1992). Inner-city asthma: The epidemiology of an emerging U.S. public health concern. Chest, 101, 362S–367S.

    Article  PubMed  CAS  Google Scholar 

  5. Maier, W. C., Arrighi, H. M., Morray, B., Llewllyn, C., & Redding, G. J. (1998). The impact of asthma and asthma-like illness in Seattle school children. Journal of Clinical Epidemiology, 51, 557–568.

    Article  PubMed  CAS  Google Scholar 

  6. Milton, B., Whitehead, M., Holland, P., & Hamilton, V. (2004). The social and economic consequences of childhood asthma across the life course: A systematic review. Child: Care, Health and Development, 30, 711–728.

    Article  CAS  Google Scholar 

  7. Newacheck, P. W., & Halfon, N. (2000). Prevalence, impact, and trends in childhood disability due to asthma. Archives of Pediatrics & Adolescent Medicine, 154, 287–293.

    CAS  Google Scholar 

  8. Annesi-Maesano, I., Moreau, D., & Strachan, D. (2001). In utero and perinatal complications preceding asthma. Allergy, 56, 491–497.

    Article  PubMed  CAS  Google Scholar 

  9. Litonjua, A. A., Carey, V. J., Burge, H. A. et al. (1998). Parental history and the risk for childhood asthma: Does mother confer more risk than father? American Journal of Respiratory and Critical Care Medicine, 158, 176–181.

    PubMed  CAS  Google Scholar 

  10. Sears, M. R. (1997). Epidemiology of childhood asthma. The Lancet, 350, 1015–1020.

    Article  CAS  Google Scholar 

  11. Cook, D. G., & Strachan, D. P. (1999). Health effects of passive smoking: Summary of effects of parental smoking on the respiratory health of children and implications for research. Thorax, 54, 357–366.

    PubMed  CAS  Google Scholar 

  12. Gilliland, F. D., Li, Y.-F., & Peters, J. M. (2001). Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. American Journal of Respiratory and Critical Care Medicine, 163(2), 429–436.

    PubMed  CAS  Google Scholar 

  13. Jaakkola, J. J. K., & Gissler, M. (2004). Maternal smoking in pregnancy, fetal development, and childhood asthma. American Journal of Public Health, 94(1), 136.

    PubMed  Google Scholar 

  14. Weitzman, M., Gortmaker, S., Walker, D. K., & Sobol, A. (1990). Maternal smoking and childhood asthma. Pediatrics, 85, 505–511.

    PubMed  CAS  Google Scholar 

  15. Calvani, M., Alessandri, C., Sopo, S. M., Panetta, V., Tripodi, S., Torre, A. et al. (2004). Infectious and uterus related complications during pregnancy and development of atopic and nonatopic asthma in children. Allergy, 59, 99–106.

    Article  PubMed  CAS  Google Scholar 

  16. Nafstad, P., Magnus, P., & Jaakkola, J. J. K. (2000). Risk of childhood asthma and allergic rhinitis in relation to pregnancy complications. The Journal of Allergy and Clinical Immunology, 106, 867–873.

    Article  PubMed  CAS  Google Scholar 

  17. Nafstad, P., Samuelsen, S. O., Irgens, L. M., & Bjerkedal, T. (2003). Pregnancy complications and the risk of asthma among Norwegians born between 1967 and 1993. European Journal of Epidemiology, 18, 755–761.

    Article  PubMed  Google Scholar 

  18. Xu, B., Pekkanen, J., & Jarvelin, M. (2000). Obstetric complications and asthma in childhood. The Journal of Asthma, 37, 589–594.

    Article  PubMed  CAS  Google Scholar 

  19. Xu, B., Pekkanen, J., Jarvelin, M. R., Olsen, P., & Hartikainen, A. L. (1999). Maternal infections in pregnancy and the development of asthma among offspring. International Journal of Epidemiology, 28, 723–727.

    Article  PubMed  CAS  Google Scholar 

  20. Xu, B., Pekkanen, J., Hartikainen, A.-L., & Jarvelin, M.-R. (2001). Caesarean section and risk of asthma and allergy in adulthood. The Journal of Allergy and Clinical Immunology, 107(4), 732.

    Article  PubMed  CAS  Google Scholar 

  21. Flaherman, V., & Rutherford, G. W. (2006). A meta-analysis of the effect of high weight on asthma. Archives of Disease in Childhood, 91, 334–339.

    Article  PubMed  CAS  Google Scholar 

  22. Leadbitter, P., Pearce, N., Cheng, S., Sears, M. R., Holdaway, D. M., Flannery, E. M. et al. (1999). Relationship between fetal growth and the development of asthma and atopy in childhood. Thorax, 54, 905–910.

    PubMed  CAS  Google Scholar 

  23. Nepomnyaschy, L., & Reichman, N. E. (2006). Low birth weight and asthma among young urban children. American Journal of Public Health, 96, 1604–1610.

    Article  PubMed  Google Scholar 

  24. Akinbami, L., LaFleur, B., & Schoendorf, K. C. (2002). Racial and income disparities in childhood asthma in the United States. Ambulatory Pediatrics, 2, 382–387.

    Article  PubMed  Google Scholar 

  25. Dik, N., Tate, R. B., Manfreda, J., & Anthonisen, N. R. (2004). Risk of physician-diagnosed asthma in the first 6 years of life. Chest, 126(4), 1147–1153.

    Article  PubMed  Google Scholar 

  26. Rasanen, M., Kaprio, J., Laitinen, T., Winter, T., Koskenvuo, M., & Laitinen, L. A. (2000). Perinatal risk factors for asthma in Finnish adolescent twins. Thorax, 55(1), 25–31.

    Article  PubMed  CAS  Google Scholar 

  27. Gdalevich, M., Mimouni, D., & Mimouni, M. (2001). Breast-feeding and the risk of bronchial asthma in childhood: A systematic review with meta-analysis of prospective studies. The Journal of Pediatrics, 139, 261–266.

    Article  PubMed  CAS  Google Scholar 

  28. Oddy, W. H., & Peat, J. K. (2003). Breastfeeding, asthma, and atopic disease: An epidemiological review of the literature. Journal of Human Lactation, 19, 250–261.

    Article  PubMed  Google Scholar 

  29. National Institutes of Health. (2004). Strategic Plan for NIH Obesity Research.

  30. Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., & Flegal, K. M. (2006). Prevalence of overweight and obesity in the United States, 1999–2004. The Journal of the American Medical Association, 295(13), 1549–1555.

    Article  CAS  Google Scholar 

  31. Dietz, W. H. Jr., & Gortmaker, S. L. (1984). Factors within the physical environment associated with childhood obesity. The American Journal of Clinical Nutrition, 39(4), 619–624.

    PubMed  Google Scholar 

  32. Jackson, E. J., Doescher, M. P., Jerant A. F., & Hart, G. L. (2005). A national study of obesity prevalence and trends by type of rural county. Journal of Rural Health, 21(2), 140–148.

    Article  PubMed  Google Scholar 

  33. National Institutes of Health (1998). Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: NIH Publication, No. 98-4083.

  34. Baeten, J. M., Bukusi, E. A., & Lambe, M. (2001). Pregnancy complications and outcomes among overweight and obese nulliparous women. American Journal of Public Health, 91, 436–440.

    Article  PubMed  CAS  Google Scholar 

  35. Cedergren, M. I. (2004). Maternal morbid obesity and the risk of adverse pregnancy outcome. Obstetrics and Gynecology, 103, 219–224.

    PubMed  Google Scholar 

  36. Lu, G. C., Rouse, D. J., DuBard, M., Cliver, S., Kimberlin, D., & Hauth, J. C. (2001). The effect of the increasing prevalence of maternal obesity on perinatal morbidity. American Journal of Obstetrics and Gynecology, 185, 845–849.

    Article  PubMed  CAS  Google Scholar 

  37. Ray, J. G., Vermeulen, M. J., Shapiro, J. L., & Kenshole, A. B. (2001). Maternal and neonatal outcomes in pregestational and gestational diabetes mellitus, and the influence of maternal obesity and weight gain: The DEPOSIT study. The Quarterly Journal of Medicine, 94, 347.

    CAS  Google Scholar 

  38. Robinson, H. E., O’Connell, C. M., Joseph, K. S., & McLeod, N. L. (2005). Maternal outcomes in pregnancies complicated by obesity. Obstetrics and Gynecology, 106, 1357–1364.

    PubMed  Google Scholar 

  39. Sebire, N. J., Jolly, M., Harris, J. P., Wadsworth, J., Joffe, M., Beard, R. W. et al. (2001). Maternal obesity and pregnancy outcome: A study of 287,213 pregnancies in London. International Journal of Obesity, 25, 1175–1182.

    Article  PubMed  CAS  Google Scholar 

  40. Vahratian, A., Zhang, J., Troendle, J. F., Savitz, D. A., & Siega-Riz, A. M. (2004). Maternal prepregnancy overweight and obesity and the pattern of labor progression in term nulliparous women. Obstetrics and Gynecology, 104, 943–951.

    PubMed  Google Scholar 

  41. Weiss, J. L., Malone, F. D., Emig, D., Ball, R. H., Nyberg, D. A., Comstock, C. H. et al. (2004). Obesity, obstetric complications and cesarean delivery rate-a population-based screening study. American Journal of Obstetrics and Gynecology, 190, 1091–1097.

    Article  PubMed  Google Scholar 

  42. Castro, L. C., & Avino, R. L. (2002). Maternal obesity and pregnancy outcomes. Current Opinion in Obstetrics & Gynecology, 14, 601–606.

    Article  Google Scholar 

  43. Watkins, M. L., Rasmussen, S. A., Honein, M. A., Botto, L. D., & Moore, C. A. (2003). Maternal obesity and risk for birth defects. Pediatrics, 111, 1152–1158.

    PubMed  Google Scholar 

  44. Stunkard, A. (1996). Socioeconomic status and obesity. Ciba Foundation Symposium, 201, 174–182.

    PubMed  CAS  Google Scholar 

  45. Healton, C. G., Vallone, D., McCausland, K. L., Xiao, H., & Green, M. P. (2006). Smoking, obesity, and their co-occurrence in the United States: Cross sectional analysis. British Medical Journal, 333, 25–26.

    Article  PubMed  Google Scholar 

  46. Rasmussen, K. M., & Kjolhede, C. L. (2004). Prepregnant overweight and obesity diminish the prolactin response to suckling in the first week postpartum. Pediatrics, 113, e465–e471.

    Article  PubMed  Google Scholar 

  47. Kim, S. Y., Dietz, P. M., England, L., Morrow, B., & Callaghan, W. M. (2007). Trends in pre-pregnancy obesity in nine states, 1993–2003. Obesity, 15(4), 986–993.

    Article  PubMed  Google Scholar 

  48. Lucas, A. (1994). Role of nutritional programming in determining adult morbidity. Archives of Disease in Childhood, 71, 288–290.

    PubMed  CAS  Google Scholar 

  49. Barker, D. (1992). Fetal and infant origins of adult disease. London: BMJ Publishing.

    Google Scholar 

  50. Barker, D. (1995). Fetal origins of coronary heart disease. British Medical Journal, 311, 171–174.

    PubMed  CAS  Google Scholar 

  51. Harding, J. E. (2001). The nutritional basis of the fetal origins of adult disease. International Journal of Epidemiology, 30, 15–23.

    Article  PubMed  CAS  Google Scholar 

  52. Armitage, J. A., Taylor, P. D., & Poston, L. (2005). Experimental models of developmental programming: Consequences of exposure to an energy rich diet during development. The Journal of Physiology, 565, 3–8.

    Article  PubMed  CAS  Google Scholar 

  53. Beuther, D. A., Weiss, S. T., & Sutherland, E. R. (2006). Obesity and asthma. American Journal of Respiratory and Critical Care Medicine, 174, 112–119.

    Article  PubMed  Google Scholar 

  54. Camargo, C. A., Jr., Weiss, S. T., Zhang, S., Willett, W. C., & Speizer, F. E. (1999). Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Archives of Internal Medicine, 159, 2582–2588.

    Article  PubMed  Google Scholar 

  55. Ford, E. S. (2005). The epidemiology of obesity and asthma. The Journal of Allergy and Clinical Immunology, 115, 897–909.

    Article  PubMed  Google Scholar 

  56. Shaheen, S. O., Sterne, J. A. C., Montgomery, S. M., & Azima, H. (1999). Birth weight, body mass index and asthma in young adults. Thorax, 54, 396–402.

    Article  PubMed  CAS  Google Scholar 

  57. Tantisira, K. G., & Weiss, S. T. (2001). Complex interactions in complex traits: Obesity and asthma. Thorax, 56, ii64–ii74.

    PubMed  Google Scholar 

  58. Reichman, N. E., Teitler, J. O., Garfinkel, I., & McLanahan, S. (2001). Fragile families: Sample and design. Children and Youth Services Review, 23, 303–326. http://www.fragilefamilies.princeton.edu/surveys/Reichman_et_al_2001.pdf

  59. StataCorp (2005). Stata Statistical Software: Release 9. In. College Station, TX: StataCorp, L. P.

  60. Center for Multilevel Modeling. (2003). MLwiN multilevel modeling. UK: University of Bristol.

    Google Scholar 

  61. Center for Disease Control and Prevention. BMI—Body Mass Index: About BMI for Children and Teens. Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion.

  62. King, J. C. (2006). Maternal obesity, metabolism, and pregnancy outcomes. Annual Review of Nutrition, 26, 271–291.

    Article  PubMed  CAS  Google Scholar 

  63. Boney, C. M., Verma, A., Tucker, R., & Vohr, B. R. (2005). Metabolic syndrome in childhood: Association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics, 115, e290–e296.

    Article  PubMed  Google Scholar 

  64. Anderson, J. L., Waller, D. K., Canfield, M. A., Shaw, G. M., Watkins, M. L., & Werler, M. M. (2005). Maternal obesity, gestational diabetes, and central nervous system birth defects. Epidemiology, 16, 87–92.

    Article  PubMed  Google Scholar 

  65. Catalano, P., & Ehrenberg, H. (2006). The short- and long-term implications of maternal obesity on the mother and her offspring. British Journal of Obstetrics and Gynaecology, 113, 1126–1133.

    PubMed  CAS  Google Scholar 

  66. Guler, N., Kirerleri, E., Ones, U., Tamay, Z., Salmayenli, N., & Darendeliler, F. (2004). Leptin: Does it have any role in childhood asthma? The Journal of Allergy and Clinical Immunology, 114, 254–259.

    Article  PubMed  CAS  Google Scholar 

  67. Xu, B., Jarvelin, M. -R., Hartikainen, A. -L., & Pekkanen, J. (2000). Maternal age at menarche and atopy among offspring at the age of 31 years. Thorax, 55, 691–693.

    Article  PubMed  CAS  Google Scholar 

  68. Hartert, T. V., Peebles, R., & Stokes, J. (2000). Epidemiology of asthma: The year in review. Current Opinion in Pulmonary Medicine, 6(1), 4–9.

    Article  PubMed  CAS  Google Scholar 

  69. Miller, J. E. (2001). Predictors of asthma in young children: Does reporting source affect our conclusions? American Journal of Epidemiology, 154(3), 245–250.

    Article  PubMed  CAS  Google Scholar 

  70. Martinez, F. D., Wright, A. L., Taussig, L. M., Holberg, C. J., Halonen, M., Morgan, W. J. et al. (1995). Asthma and wheezing in the first six years of life. The New England Journal of Medicine, 332(3), 133–138.

    Article  PubMed  CAS  Google Scholar 

  71. Joseph, C. L. M., Foxman, B., Leickly, F. E., Peterson, E., & Ownby, D. (1996). Prevalence of possible undiagnosed asthma and associated morbidity among urban schoolchildren. Journal of Pediatr, 129(5), 735–742.

    Article  CAS  Google Scholar 

  72. Akinbami, L. J., Rhodes, J. C., & Lara, M. (2005). Racial and ethnic differences in asthma diagnosis among children who wheeze. Pediatrics, 115(5), 1254–1260.

    Article  PubMed  Google Scholar 

  73. Morland, K., Diez Roux, A. V., & Wing, S. (2006). Supermarkets, other food stores, and obesity: The atherosclerosis risk in communities study. American Journal of Preventive Medicine 30, 333–339.

    Article  PubMed  Google Scholar 

  74. Moore, L. V., & Diez Roux, A. V. (2006). Associations of neighborhood characteristics with the location and type of food stores. American Journal of Public Health, 96, 325–331.

    Article  PubMed  Google Scholar 

  75. Rauh, V. A., Chew, G. L., & Garfinkel, R. S. (2002). Deteriorated housing contributes to high cockroach allergen levels in inner-city households. Environmental Health Perspectives, 110, 161–171.

    Google Scholar 

  76. Breysse, P. N., Galke, W., Lanphear, B. P., & Farr, N. (2003). The relationship between housing and health: Children at risk workshop. Columbia: National Center for Healthy Housing.

    Google Scholar 

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Acknowledgement

This research was supported by the National Institute of Child Health and Human Development Grant R01HD35301. We thank Andrew Gelman for statistical advice.

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Correspondence to Nancy E. Reichman.

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Reichman, N.E., Nepomnyaschy, L. Maternal Pre-Pregnancy Obesity and Diagnosis of Asthma in Offspring at Age 3 Years. Matern Child Health J 12, 725–733 (2008). https://doi.org/10.1007/s10995-007-0292-2

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