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Risk factors shared by COPD and lung cancer and mediation effect of COPD: two center case–control studies

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Abstract

Purpose

To reveal the shared risk factors for chronic obstructive pulmonary disease (COPD) and lung cancer, and to analyze the mediation effect of COPD during lung carcinogenesis.

Methods

We conducted four independent case–control studies included 1,511 COPD patients and 1,677 normal lung function controls and 1,559 lung cancer cases and 1,679 cancer-free controls during 2002–2011 in southern and eastern Chinese.

Results

Eight factors were observed to be consistently associated with both diseases risk, including pre-existing tuberculosis, smoking, passive smoking, occupational exposure to metallic toxicant, poor housing ventilation, biomass burning, cured meat consumption, and seldom vegetables/fruits consumption. Furthermore, smoking and biomass burning conferred significantly higher risk effects on lung cancer in individuals with pre-existing COPD than those without. COPD also had significant mediation effects during lung carcinogenesis caused by smoking, passive smoking, and biomass burning, which explained about 12.0 % of effect, 3.8 % of effect, and 6.1 % of effect of these factors on lung tumorigenesis in turn.

Conclusion

Our study mapped a shared spectrum of etiological factors for both COPD and lung cancer in Chinese, and COPD acts as a mediator during lung cancer development. These observations should be in consideration for the prevention of both diseases.

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Acknowledgments

This study was supported by the National Natural Scientific Foundation of China Grants 30671813, 30872178, 81072366, 81273149, 81473040 (J. Lu), and partly by 81001278, 81171895, 81472630 (Y. Zhou); 81402753 (L. Yang), 81102159 (L. Zhang), 81102061 (Q. Jiang), 30972540 (B. Liu); and Guangdong Provincial High Level Experts Grants 2010-79 (J. Lu). We thank Dr. Zhanhong Xie, Dr. Wanmin Zeng and Dr. Ling Liu for their assistances in recruiting the subjects; Dr. Lisha Zhang for their laboratory assistances.

Conflict of interest

No conflict of interest exists for any author.

Author information

Authors and Affiliations

  1. The State Key Lab of Respiratory Disease, The Institute for Chemical Carcinogenesis, Collaborative Innovation Center for Environmental Toxicity, Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou, 510182, China

    Lei Yang, Xiaoxiao Lu, Fuman Qiu, Xiaorong Yang, Rongrong Yang, Wenxiang Fang & Jiachun Lu

  2. School of Arts and Sciences, Colby-Sawyer College, New London, NH, 03257, USA

    Xiaoxiao Lu

  3. Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou, 215123, China

    Jieqiong Deng & Yifeng Zhou

  4. The State Key Lab of Respiratory Disease, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China

    Yumin Zhou, Pixin Ran & Nanshan Zhong

  5. Department of Respiratory Medicine, Guangzhou Chest Hospital, Guangzhou, 510095, Guangdong, China

    Dongsheng Huang

  6. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Shenying Fang

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  1. Lei Yang
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Corresponding author

Correspondence to Jiachun Lu.

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Yang, L., Lu, X., Deng, J. et al. Risk factors shared by COPD and lung cancer and mediation effect of COPD: two center case–control studies. Cancer Causes Control 26, 11–24 (2015). https://doi.org/10.1007/s10552-014-0475-2

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  • DOI: https://doi.org/10.1007/s10552-014-0475-2

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