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Nonspecific interstitial pneumonia pattern as pulmonary involvement of rheumatoid arthritis

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Abstract

The pathologic patterns of lung involvement were evaluated in 16 patients with rheumatoid arthritis (RA). They consisted of six females and ten males, with a median age of 67.5 years and diagnosed according to the American Rheumatism Association revised criteria. High-resolution computed tomography (HRCT) of the lungs was performed in all patients, and honeycomb formation was apparent in seven. Histopathologically, seven patients were diagnosed with usual interstitial pneumonia (UIP) pattern, seven with nonspecific interstitial pneumonia/fibrosis (NSIP) pattern, and two with UIP/NSIP hybrid pattern. There were no apparent honeycomb formations on HRCT in patients diagnosed with NSIP pattern. In conclusion, the present study demonstrates that NSIP pattern is also a significant histologic classification of interstitial pneumonia associated with RA.

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Authors and Affiliations

  1. Toyokawa City Hospital, Toyokawa, Aichi, Japan

    T. Yoshinouchi

  2. Department of Tumor Pathology, Kochi University, Kochi, Japan

    Y. Ohtsuki

  3. First Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750-1 Miki-cho, Kita-gun, Kagawa 761-0793, Japan

    J. Fujita, S. Bandoh & T. Ishida

  4. Clinical Laboratory Department, National Okayama Medical Center, Okayama, Japan

    I. Yamadori

  5. Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Science, Aichi, Japan

    R. Ueda

Authors
  1. T. Yoshinouchi
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  2. Y. Ohtsuki
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  3. J. Fujita
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  4. I. Yamadori
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  5. S. Bandoh
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  6. T. Ishida
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  7. R. Ueda
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Correspondence to J. Fujita.

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Yoshinouchi, T., Ohtsuki, Y., Fujita, J. et al. Nonspecific interstitial pneumonia pattern as pulmonary involvement of rheumatoid arthritis. Rheumatol Int 26, 121–125 (2005). https://doi.org/10.1007/s00296-004-0527-0

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  • DOI: https://doi.org/10.1007/s00296-004-0527-0

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