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IL-17RC: a partner in IL-17 signaling and beyond

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Abstract

The interleukin (IL)-17 cytokine family members IL-17A and IL-17F mediate inflammatory activities via the IL-17 receptor (IL-17R) complex, comprised of the IL-17RA and IL-17RC subunits. Proper regulation of the IL-17 signaling axis results in effective host defense against extracellular pathogens, while aberrant signaling can drive autoimmune pathology. Elucidating the molecular mechanisms underlying IL-17 signal transduction can yield an enhanced understanding of inflammatory immune processes and also create an avenue for therapeutic intervention in the treatment of IL-17-dependent diseases. To date, the fundamental signaling mechanisms used by the IL-17R complex are still incompletely defined. While current structure–function studies have primarily focused on the IL-17RA subunit, recent research indicates that the IL-17RC subunit plays a key role in modulating IL-17 responses. This review will examine what is known regarding IL-17RC function and provide a framework for future work on this subunit and its impact on human health.

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Acknowledgments

This work was supported by the Medical Scientist Training Program at the University at Buffalo (SUNY) School of Medicine and Biomedical Sciences. SLG was supported by the NIH (AR054389), Amgen, and the Alliance for Lupus Research. We thank Dr. Brett N. Tomson for valuable comments and assistance with the manuscript.

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  1. Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, NY, 14214, USA

    Allen W. Ho & Sarah L. Gaffen

  2. Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, BST S708, 3500 Terrace St, Pittsburgh, PA, 15261, USA

    Allen W. Ho & Sarah L. Gaffen

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  1. Allen W. Ho
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  2. Sarah L. Gaffen
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Correspondence to Sarah L. Gaffen.

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Ho, A.W., Gaffen, S.L. IL-17RC: a partner in IL-17 signaling and beyond. Semin Immunopathol 32, 33–42 (2010). https://doi.org/10.1007/s00281-009-0185-0

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  • DOI: https://doi.org/10.1007/s00281-009-0185-0

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