Skip to main content
Log in

Radiological Management of Hemoptysis: A Comprehensive Review of Diagnostic Imaging and Bronchial Arterial Embolization

  • Review/State of the Art
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Hemoptysis can be a life-threatening respiratory emergency and indicates potentially serious underlying intrathoracic disease. Large-volume hemoptysis carries significant mortality and warrants urgent investigation and intervention. Initial assessment by chest radiography, bronchoscopy, and computed tomography (CT) is useful in localizing the bleeding site and identifying the underlying cause. Multidetector CT angiography is a relatively new imaging technique that allows delineation of abnormal bronchial and nonbronchial arteries using reformatted images in multiple projections, which can be used to guide therapeutic arterial embolization procedures. Bronchial artery embolization (BAE) is now considered to be the most effective procedure for the management of massive and recurrent hemoptysis, either as a first-line therapy or as an adjunct to elective surgery. It is a safe technique in the hands of an experienced operator with knowledge of bronchial artery anatomy and the potential pitfalls of the procedure. Recurrent bleeding is not uncommon, especially if there is progression of the underlying disease process. Prompt repeat embolization is advised in patients with recurrent hemoptysis in order to identify nonbronchial systemic and pulmonary arterial sources of bleeding. This article reviews the pathophysiology and causes of hemoptysis, diagnostic imaging and therapeutic options, and technique and outcomes of BAE.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10

Similar content being viewed by others

References

  1. Haponik EF, Fein A, Chin R (2000) Managing life-threatening hemoptysis: has anything really changed? Chest 118:1431–1435

    Article  PubMed  CAS  Google Scholar 

  2. Crocco JA, Rooney JJ, Fankushen DS et al (1968) Massive hemoptysis. Arch Intern Med 121:495–498

    Article  PubMed  CAS  Google Scholar 

  3. Najarian KE, Morris CS (1998) Arterial embolization in the chest. J Thorac Imaging 13:93–104

    Article  PubMed  CAS  Google Scholar 

  4. Fernando HC, Stein M, Benfield JR et al (1998) Role of bronchial artery embolization in the management of hemoptysis. Arch Surg 133:862–866

    Article  PubMed  CAS  Google Scholar 

  5. Pump K (1972) Distribution of bronchial arteries in human lung. Chest 62:447–451

    Article  PubMed  CAS  Google Scholar 

  6. Deffebach ME, Charan NB, Lakshminarayan S et al (1987) The bronchial circulation: small but a vital attribute to the lung. Am Rev Respir Dis 135:463–481

    PubMed  CAS  Google Scholar 

  7. Malik AB, Tracy SE (1980) Bronchovascular adjustments after pulmonary embolism. J Appl Physiol 49:476–481

    PubMed  CAS  Google Scholar 

  8. Ferris EJ (1981) Pulmonary hemorrhage. Vascular evaluation and interventional therapy. Chest 80:710–714

    Article  PubMed  CAS  Google Scholar 

  9. Marshall TJ, Jackson JE (1997) Vascular intervention in the thorax: bronchial artery embolization for haemoptysis. Eur Radiol 7:1221–1227

    Article  PubMed  CAS  Google Scholar 

  10. McDonald DM (2001) Angiogenesis and remodeling of airway vasculature in chronic inflammation. Am J Respir Crit Care Med 164:S39–S45

    PubMed  CAS  Google Scholar 

  11. Yoon W, Kim JK, Kim YH et al (2002) Bronchial and nonbronchial systemic artery embolization for life-threatening hemoptysis: a comprehensive review. Radiographics 22:1395–1409

    Article  PubMed  Google Scholar 

  12. Jean–Baptiste E (2000) Clinical assessment and management of massive hemoptysis. Crit Care Med 28:1642–1647

    Article  PubMed  Google Scholar 

  13. Hirshberg B, Biran I, Glazer M et al (1997) Hemoptysis: etiology, evaluation and outcome in a tertiary referral hospital. Chest 112:440–444

    Article  PubMed  CAS  Google Scholar 

  14. Hiyama J, Horita N, Shiota Y et al (2002) Cryptogenic hemoptysis and smoking. Chest 121:1375–1376

    Article  PubMed  Google Scholar 

  15. Bruzzi JF, Rémy-Jardin M, Delhaye D et al (2006) Multi-detector row CT of hemoptysis. Radiographics 26:3–22

    Article  PubMed  Google Scholar 

  16. Dweik RA, Stoller JK (1999) Role of bronchoscopy in massive hemoptysis. Clin Chest Med 20:89–105

    Article  PubMed  CAS  Google Scholar 

  17. Hsiao EI, Kirsch CM, Kagawa FT et al (2001) Utility of fibre-optic bronchoscopy before bronchial artery embolization for massive hemoptysis. AJR 177:861–867

    PubMed  CAS  Google Scholar 

  18. Herth F, Ernst A, Becker HD (2001) Long-term outcome and lung cancer incidence in patients with hemoptysis of unknown origin. Chest 120:1592–1594

    Article  PubMed  CAS  Google Scholar 

  19. Abal AT, Nair PC, Cherian J (2001) Haemoptsis: aetiology, evaluation and outcome—a prospective study in a third world country. Respir Med 95:548–552

    Article  PubMed  CAS  Google Scholar 

  20. Song JW, Im JG, Shim YS et al (1998) Hypertrophied bronchial artery at thin-section CT in patients with bronchiectasis: correlation with CT angiographic findings. Radiology 208:187–191

    PubMed  CAS  Google Scholar 

  21. Do KH, Goo JM, Im JG et al (2001) Systemic arterial supply to the lungs in adults: spiral CT findings. Radiographics 21:387–402

    PubMed  CAS  Google Scholar 

  22. Yoon W, Kim YH, Kim JK et al (2003) Massive hemoptysis: prediction of nonbronchial systemic arterial supply with chest CT. Radiology 227:232–238

    Article  PubMed  Google Scholar 

  23. Remy-Jardin M, Bouaziz N, Dumont P et al (2004) Bronchial and nonbronchial systemic arteries at multi-detector row CT angiography: comparison with conventional angiography. Radiology 233:741–749

    Article  PubMed  Google Scholar 

  24. Hartmann IJ, Remy-Jardin M, Menchini L et al (2007) Ectopic origin of bronchial arteries: assessment with multidetector helical CT angiography. Eur Radiol 17:1943–1953

    Article  PubMed  Google Scholar 

  25. Chung MJ, Lee JH, Lee KS et al (2006) Bronchial and nonbronchial systemic arteries in patients with hemoptysis: depiction on MDCT angiography. AJR 186:649–655

    Article  PubMed  Google Scholar 

  26. Yoon YC, Lee KS, Jeong YJ et al (2005) Hemoptysis: bronchial and nonbronchial systemic arteries at 16-detector row CT. Radiology 234:292–298

    Article  PubMed  Google Scholar 

  27. Khalil A, Fartoukh M, Tassart M et al (2007) Role of MDCT in identification of the bleeding site and the vessels causing hemoptysis. AJR 188:W117–W125

    Article  PubMed  Google Scholar 

  28. Garzon AA, Gourin A (1978) Surgical management of massive hemoptysis: a ten-year experience. Ann Surg 187:267–271

    Article  PubMed  CAS  Google Scholar 

  29. Garzon AA, Cerruti M, Gourin A et al (1970) Pulmonary resection for massive hemoptysis. Surgery 67:633–638

    PubMed  CAS  Google Scholar 

  30. Shigemura N, Wan IY, Yu SC et al (2009) Multidisciplinary management of life–threatening massive hemoptysis: a 10-year experience. Ann Thorac Surg 87:849–853

    Article  PubMed  Google Scholar 

  31. Remy J, Arnaud A, Fardou H et al (1977) Treatment of hemoptysis by embolization of bronchial arteries. Radiology 122:33–37

    PubMed  CAS  Google Scholar 

  32. Uflacker R, Kaemmerer A, Picon PD et al (1985) Bronchial artery embolization in the management of hemoptysis: technical aspects and long-term results. Radiology 157:637–644

    PubMed  CAS  Google Scholar 

  33. Rabkin JE, Astafjev VI, Gothman LN et al (1987) Transcatheter embolization in the management of pulmonary hemorrhage. Radiology 163:361–365

    PubMed  CAS  Google Scholar 

  34. Katoh O, Kishikawa T, Yamada H et al (1990) Recurrent bleeding after arterial embolization in patients with hemoptysis. Chest 97:541–546

    Article  PubMed  CAS  Google Scholar 

  35. Hayakawa K, Tanaka F, Torizuka T et al (1992) Bronchial artery embolization for hemoptysis: immediate and long-term results. CardioVasc Interv Radiol 15:154–158

    Article  CAS  Google Scholar 

  36. Ramakantan R, Bandekar VG, Gandhi MS et al (1996) Massive hemoptysis due to pulmonary tuberculosis: control with bronchial artery embolization. Radiology 200:694

    Google Scholar 

  37. Mal H, Rullon I, Mellot F et al (1999) Immediate and long-term results of bronchial artery embolization for life-threatening hemoptysis. Chest 115:996–1001

    Article  PubMed  CAS  Google Scholar 

  38. Swanson KL, Johnson M, Prakash UB et al (2002) Bronchial artery embolization: experience with 54 patients. Chest 121:789–795

    Article  PubMed  Google Scholar 

  39. Poyanli A, Acunas B, Rozanes I et al (2007) Endovascular therapy in the management of moderate and massive haemoptysis. Br J Radiol 80:331–336

    Article  PubMed  CAS  Google Scholar 

  40. Williams JR, Wilcox WC, Burns RR (1963) Angiography of the systemic pulmonary circulation. Am J Roentgenol AJR 90:614–627

    CAS  Google Scholar 

  41. Neyazaki T (1962) A method for arteriography of the bronchial artery. Jpn Heart J 3:523–536

    PubMed  CAS  Google Scholar 

  42. Viamonte M Jr (1964) Selective bronchial arteriography in man: preliminary report. Radiology 83:830–839

    PubMed  Google Scholar 

  43. Feigelson HH, Ravin HA (1965) Transverse myelitis following selective bronchial arteriography. Radiology 85:663–665

    PubMed  CAS  Google Scholar 

  44. Kardjiev V, Symeonov A, Chankov I (1974) Etiology, pathogenesis and prevention of spinal cord lesions in selective angiography of the bronchial and intercostal arteries. Radiology 112:81–83

    PubMed  CAS  Google Scholar 

  45. Di Chiro G (1974) Unintentional spinal cord arteriography: a warning. Radiology 112:231–233

    PubMed  CAS  Google Scholar 

  46. Remy J, Voisin C, Dupuis C et al (1974) Traitement des hemoptysies par embolization de la circulation systemique. Ann Radiol (Paris) 17:5–16

    CAS  Google Scholar 

  47. Uflacker R, Kaemmerer A, Neves C et al (1983) Management of massive hemoptysis by bronchial artery embolization. Radiology 146:627–634

    PubMed  CAS  Google Scholar 

  48. Brinson GM, Noone PG, Mauro MA et al (1998) Bronchial artery embolization for the treatment of hemoptysis in patients with cystic fibrosis. Am J Respir Crit Care Med 157:1951–1958

    PubMed  CAS  Google Scholar 

  49. Yu-Tang Goh P, Lin M, Teo N et al (2002) Embolization for hemoptysis: a six-year review. CardioVasc Interv Radiol 25:17–25

    Article  Google Scholar 

  50. Kato A, Kudo S, Matsumoto K et al (2000) Bronchial artery embolization for hemoptysis due to benign diseases: immediate and long-term results. CardioVasc Interv Radiol 23:351–357

    Article  CAS  Google Scholar 

  51. Cauldwell EW, Siekert RG, Lininger RE et al (1948) The bronchial arteries: an anatomic study of 150 human cadavers. Surg Gynecol Obstet 86:395–412

    PubMed  CAS  Google Scholar 

  52. Botenga AS (1968) The role of bronchopulmonary anastomoses in chronic inflammatory processes of the lung. Selective arteriographic investigation. Am J Roentgenol Radium Ther Nucl Med 104:829–837

    PubMed  CAS  Google Scholar 

  53. Sancho C, Escalante E, Dominguez J et al (1998) Embolization of bronchial arteries of anomalous origin. CardioVasc Interv Radiol 21:300–304

    Article  CAS  Google Scholar 

  54. Stoll JF, Bettmann MA (1988) Bronchial artery embolization to control hemoptysis: a review. CardioVasc Interv Radiol 11:263–269

    Article  CAS  Google Scholar 

  55. Keller FS, Rosch J, Loflin TG et al (1987) Nonbronchial systemic collateral arteries: significance in percutaneous embolotherapy for hemoptysis. Radiology 164:692

    Google Scholar 

  56. Remy J, Lemaitre L, Lafitte JJ et al (1984) Massive hemoptysis of pulmonary arterial origin: diagnosis and treatment. AJR 143:963–969

    PubMed  CAS  Google Scholar 

  57. Sbano H, Mitchell AW, Ind PW et al (2005) Peripheral pulmonary artery pseudoaneurysms and massive hemoptysis. AJR 184:1253–1259

    PubMed  Google Scholar 

  58. Muthuswamy PP, Akbik F, Franklin C et al (1987) Management of major or massive hemoptysis in active tuberculosis by bronchial artery embolization. Chest 92:77–82

    Article  PubMed  CAS  Google Scholar 

  59. Picard C, Parrot A, Boussard V et al (2003) Massive hemoptysis due to Rasmussen aneurysm: detection with helocoidal CT angiography and successful coil embolization. Intensive Care Med 29:1837–1839

    Article  PubMed  Google Scholar 

  60. Auerbach O (1939) Pathology and pathogenesis of pulmonary artery aneurysm in tuberculous cavity. Am Rev Tuberc 39:99–115

    Google Scholar 

  61. Ference BA, Shannon TM, White RI Jr et al (1994) Life-threatening pulmonary hemorrhage with pulmonary arteriovenous malformations and hereditary hemorrhagic telangectasia. Chest 106:1387–1390

    Article  PubMed  CAS  Google Scholar 

  62. White RI Jr, Pollak JS, Wirth JA (1996) Pulmonary arteriovenous malformations: diagnosis and transcatheter embolotherapy. J Vasc Interv Radiol 7:787–804

    Article  PubMed  Google Scholar 

  63. Pollak JS, Saluja S, Thabet A et al (2006) Clinical and anatomic outcomes after embolotherapy of pulmonary arteriovenous malformations. J Vasc Interv Radiol 17:35–44

    Article  PubMed  Google Scholar 

  64. Andersen PE (2006) Imaging and interventional radiological treatment of hemoptysis. Acta Radiol 47:780–792

    Article  PubMed  CAS  Google Scholar 

  65. Phillips S, Ruttley MS (2000) Bronchial artery embolization: the importance of preliminary thoracic angiography. Clin Radiol 55:317–319

    Article  PubMed  CAS  Google Scholar 

  66. Tanaka N, Yamakado K, Murashima S et al (1997) Superselective bronchial artery embolization for hemoptysis with a coaxial microcatheter system. J Vasc Interv Radiol 8:65–70

    Article  PubMed  CAS  Google Scholar 

  67. White RI Jr (1999) Bronchial artery embolotherapy for control of acute hemoptysis: analysis of outcome. Chest 115:912–915

    Article  PubMed  Google Scholar 

  68. Corr PD (2005) Bronchial artery embolization for life-threatening hemoptysis using tris-acryl microspheres: short-term result. Cardiovasc Interv Radiol 28:439–441

    Article  Google Scholar 

  69. Baltacioglu F, Cimsit NC, Bostanci K, et al. (2008) Transarterial microcatheter glue embolization of the bronchial artery for life-threatening hemoptysis: technical and clinical results. Eur J Radiol [Epub ahead of print]

  70. Chun JY, Belli AM (2009) Immediate and long-term outcomes of bronchial and non-bronchial systemic artery embolisation for the management of haemoptysis. Eur Radiol [Epub ahead of print]

  71. Park HS, Kim YI, Kim HY et al (2007) Bronchial artery and systemic artery embolization in the management of primary lung cancer patients with hemoptysis. Cardiovasc Interv Radiol 30:638–643

    Article  Google Scholar 

  72. Lee S, Chan JW, Chan SC et al (2008) Bronchial artery embolisation can be equally safe and effective in the management of chronic recurrent haemoptysis. Hong Kong Med J 14:14–20

    PubMed  Google Scholar 

  73. Kim YG, Yoon HK, Ko GY et al (2006) Long-term effect of bronchial artery embolization in Korean patients with haemoptysis. Respirology 11:776–781

    Article  PubMed  Google Scholar 

  74. Osaki SI, Nakanishi Y, Wataya H et al (2000) Prognosis of bronchial artery embolization in the management of hemoptysis. Respiration 67:412–416

    Article  PubMed  CAS  Google Scholar 

  75. Tonkin IL, Hanissian AS, Boulden TF et al (1991) Bronchial arteriography and embolotherapy for hemoptysis in patients with cystic fibrosis. CardioVasc Interv Radiol 14:241–246

    Article  CAS  Google Scholar 

  76. Cohen AM, Doershuk CF, Stern RC (1990) Bronchial artery embolization to control hemoptysis in cystic fibrosis. Radiology 175:401–405

    PubMed  CAS  Google Scholar 

  77. Wong ML, Szkup P, Hopley MJ (2002) Percutaneous embolotherapy for life-threatening hemoptysis. Chest 121:95–102

    Article  PubMed  Google Scholar 

  78. Girard P, Baldeyrou P, Lemoine G et al (1990) Left mainstem bronchial artery stenosis complicating bronchial artery embolization. Chest 97:1246–1248

    Article  PubMed  CAS  Google Scholar 

  79. Lemoigne F, Rampal P, Petersen R (1983) Fatal ischaemic colitis after bronchial artery embolization. Presse Med 12:2056–2057

    PubMed  CAS  Google Scholar 

  80. Munk PL, Morris DC, Nelems B (1990) Left main bronchial-esophageal fistula: a complication of bronchial artery embolization. Cardiovasc Interv Radiol 13:95–97

    Article  CAS  Google Scholar 

  81. Liu SF, Lee TY, Wong SL et al (1998) Transient cortical blindness: a complication of bronchial artery embolization. Respir Med 92:983–986

    Article  PubMed  CAS  Google Scholar 

  82. Ivanick MJ, Thorwarth W, Donohue J et al (1983) Infarction of the left main-stem bronchus: a complication of bronchial artery embolization. AJR 141:535–537

    PubMed  CAS  Google Scholar 

Download references

Ackowledgment

We would like to thank Dr. Robin Swain for his assistance in the preparation of this manuscript.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Joo-Young Chun.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chun, JY., Morgan, R. & Belli, AM. Radiological Management of Hemoptysis: A Comprehensive Review of Diagnostic Imaging and Bronchial Arterial Embolization. Cardiovasc Intervent Radiol 33, 240–250 (2010). https://doi.org/10.1007/s00270-009-9788-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00270-009-9788-z

Keywords

Navigation