Abstract
We studied serum acute phase reactant (APR) levels in 45 pediatric surgical patients. Alpha 1-acid glycoprotein (α1-AG) showed a peak value on day 3 postoperatively (P.O.) and alpha 1-antitrypsin (α1-AT) showed a high value on days 3–5 P.O. These glycoproteins returned to normal levels by day 21 P.O., but the level of haptoglobin (Hp) remained high until day 21 P.O. The postoperative changes of α1-AG and α1-AT correlated with the process of recovery from inflammatory conditions, but C-reactive protein (CRP) reached a peak on days 1–2 P.O. and returned to normal limits by day 14 P.O. In patients with infection, CRP returned to the normal level rapidly before recovery from infection. Of the 3 glycoproteins, α1-AG seemed to be a valuable indicator of the pathological conditions. Postoperative changes in APR levels should be useful for early detection of postoperative complications. Persistent ileus led to an increase in APR levels, as a consequence of an inflammatory reaction due to breakdown of the intestinal mucosal barrier.
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Ito, H., Kishikawa, T., Yamakawa, Y. et al. Serum acute phase reactants in pediatric patients; Especially in neonates. The Japanese Journal of Surgery 13, 506–511 (1983). https://doi.org/10.1007/BF02469494
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DOI: https://doi.org/10.1007/BF02469494