Summary
The gender-specific prevalence of lymphangioleiomyomatosis (LAM) in premenopausal women suggests a hormonal etiology. Despite the antiestrogenic treatment (ovariectomy, tamoxifen) this disease is often refractory to therapy and almost inevitably leads to the patient's death. We describe a case where the antiproliferative effect of systemically applied interferon alpha 2b was successfully employed in addition to ovariectomy and the patient reached complete remission.
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Klein, M., Krieger, O., Ruckser, R. et al. Treatment of lymphangioleiomyomatosis by ovariectomy, interferon alpha 2b and tamoxifen — a case report. Arch Gynecol Obstet 252, 99–102 (1992). https://doi.org/10.1007/BF02389635
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DOI: https://doi.org/10.1007/BF02389635