Abstract
IgG subclass levels were determined in 448 normal children from 6 months to 18 years of age and in 141 healthy adults by radial immunodiffusion using monoclonal antibodies. Age-normal percentile values were calculated for each year of age up to 18 years for IgG1, IgG2, IgG3 and in adults for all four subclasses. The broad spread of IgG4 values in children did not permit calculation of reference values.
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Aucouturier P, Mounir S, Preud' homme JL (1985) Distribution of IgG subclass levels in normal adult sera as determined by a competitive enzyme immunoassay using monoclonal antibodies. Diagn Immunol 3:191–197
Bass JL, Nuss R, Mehta KA, Morganelli P, Bennett L (1983) Recurrent meningococcemia associated with IgG2 subclass deficiency. N Engl J Med 309:430
Beck CS, Heiner DC (1981) Selective IgG4 deficiency and recurrent infections of the respiratory tract. Ann Rev Resp Dis 124: 94–93
Berger M (1987) Immunoglobulin G subclass determination in diagnosis and management of antibody deficiency syndromes. J Pediatr 110:325–328
Bird D, Duffy S, Isaacs D, Webster ADB (1985) Reference ranges for IgG subclasses in preschool children. Arch Dis Child 60:204–207
Cleveland WS (1979) Robust locally weighted regression and smoothing scatterplots. J Am Stat Assoc 74:829–836
Cunningham-Rundles C, Oxelius VA, Good RA (1983) IgG2 and IgG3 subclass deficiencies in selective IgA deficiency in the United States. In: Wedgwood RJ, Rosen FS, Paul NW (eds) Primary immunodeficiency diseases, Birth Defects: Original Article Series, Vol 15. Liss, New York, pp 173–175
Ferrante A, Rowan-Kelly B, Beard LJ, Maxwell GM (1986) An enzyme-linked immunosorbent assay for the quantitation of human IgG subclasses using monoclonal antibodies. J Immunol Methods 93:207–212
French MAH, Harrison G (1984) Serum IgG subclass concentrations in healthy adults: a study using monoclonal antisera. Clin Exp Immunol 56:473–475
Mancini G, Carbonara AO, Heremans JF (1965) Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 2:235–254
Matter L, Wilhelm JA, Angehrn W, Skvaril F, Schopfer K (1985) Selective antibody deficiency and recurrent pneumococcal bacteremia in a patients with Sjogren's syndrome, hyperimmunoglobulinemia G, and deficiencies of IgG2 and IgG4. N Engl J Med 312:1039–1042
Morell A, Skvaril F, Hitzig WH, Barandun S (1972) IgG-subclasses: development of the serum concentrations in normal infants and children. J Pediatr 80:960–964
Morell A, Skvaril F, Steinberg AG, Van Loghem E, Terry WD (1972) Correlation between the concentrations of the four subclasses of IgG and Gm allotypes in normal human sera. J Immunol 108:195–205
Oxelius VA (1979) Quantitative and qualitative investigations of serum IgG subclasses in immunodeficiency diseases. Clin Exp Immunol 36:112–116
Oxelius VA (1979) IgG subclass levels in infancy and childhood. Acta Paediatr Scand 68:23–27
Oxelius VA (1984) Immunoglobulin G subclasses and human disease. Am J Med 76:7–18
Oxelius VA, Svenningsen WW (1984) IgG subclass concentrations in preterm neonates. Acta Paediatr Scand 73:626–630
Oxelius VA, Laurall AB, Lindquist B, Golebiowska H, Axelsson U, Bjorkander J, Hanson LA (1981) IgG subclass in selective IgA deficiency. N Engl J Med 304:1476–1477
Oxelius VA, Izzet Berkel A, Hanson LA (1982) IgG2 deficiency in ataxia-telangiectasia. N Engl J Med 306:515–517
Plebani A, Duse M, Monafo V (1985) Recurrent infections with IgG2 deficiency. Arch Dis Child 60:670–672
Reen DJ, Murphy MB, O'Conner A, Fitzgerald MX (1981) IgG subclasses in healthy Irish adults. A population study. Ir J Med Sci 150:265–269
Schackelford PG, Polmar SH, Mayus JL, Johnson WL, Corry JM, Nahm MH (1986) Spectrum of IgG2 subclass deficiency in children with recurrent infections: prospective study. J Pediatr 108:647–652
Schur PH, Borel H, Gelfand EW, Alper CA, Rosen FS (1970) Selective gamma-G globulin deficiencies in patients with recurrent infections. N Engl J Med 283:631–634
Schur PH, Rosen F, Norman ME (1979) Immunoglobulin subclasses in normal children. Pediatr Res 13:181–183
Shakib F, Stanworth DR, Drew R, Catty D (1975) A quantitative study of the distribution of IgG subclasses in a group of normal human sera. J Immunol Methods 8:17–23
Smith TF, Morris EC, Brain RP (1984) IgG subclasses in non allergic children with chronic chest symptoms. J Pediatr 105:896–900
Ugazio AG, Out TA, Plebani A, Duse M, Monafo V, Nespoli L, Burgio GR (1983) Recurrent infections in children with selective IgA deficiency: association with IgG2 and IgG4 deficiency. In: Wedgwood RJ, Rosen FS, Paul NW (eds) Primary immunodeficiency diseases, Birth Defects: Original Article Series, vol 19. Liss, New York, pp 169–171
Umetsu DT, Ambrosino DM, Quinti I, Siber GR, Geha RS (1985) Recurrent sinopulmonary infection and impaired antibody response to bacterial capsular polysaccharide antigen in children with selective IgG-subclass deficiency. N Engl J Med 313:1247–1251
Van Der Giessen M, Rossouw E, Algra-van Veen T, Van Loghem E, Zegers BJM, Sander PC (1975) Quantification of IgG subclases in sera of normal adults and healthy children between 4 and 12 years of age. Clin Exp Immunol 21:501–509
Yount WJ, Hong R, Seligmann M, Good P, Kunkel HG (1970) Imbalance of gamma globulin subgroups and gene defects in patients with primary hypogammaglobulinemia. J Clin Invest 49:1957–1976
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Plebani, A., Ugazio, A.G., Avanzini, M.A. et al. Serum IgG subclass concentrations in healthy subjects at different age: Age normal percentile charts. Eur J Pediatr 149, 164–167 (1989). https://doi.org/10.1007/BF01958271
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DOI: https://doi.org/10.1007/BF01958271