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Muscle lipofuscin content and satellite cell volume is increased after high altitude exposure in humans

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Summary

Muscle ultrastructural changes during a typical expedition to the Himalayas were analyzed by taking muscle biopsies from seven climbers before and after their sojourn at high altitude (over 5000 m for 8 weeks). M. vastus lateralis samples were analyzed morphometrically from electron micrographs. A quantitative evaluation was made of lipofuscin, satellite cells and myonuclei. Significant increases of the volume densities of lipofuscin (+235%) and satellite cells (+215%) were observed.

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Martinelli, M., Winterhalder, R., Cerretelli, P. et al. Muscle lipofuscin content and satellite cell volume is increased after high altitude exposure in humans. Experientia 46, 672–676 (1990). https://doi.org/10.1007/BF01939930

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  • DOI: https://doi.org/10.1007/BF01939930

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