Abstract
The prevalence, persistence, incidence and remission rates of reported diagnosed asthma and chronic bronchitis has been studied longitudinally over ten years in a representative community sample of children and adolescents. The objectives are to evaluate the rates of change over time, the role of family history of disease, and the social risk factors in the longitudinal course of disease. The relationship between the two reported diagnoses is very high, about half of each group having the other diagnosis. Each diagnosis has specific symptoms with which it is associated. Remission of clinical disease is associated with continuing symptoms in about half of such cases. The incidence rates and remissions of cases as they have occurred over time were associated with different symptoms and risk factors. A family history of lung disease and family social characteristics are significant risk factors affecting the presence of these diseases, and how they change. Discussion suggests these factors may affect possible precursors, such as lower respiratory tract illnesses, as well as personal habits (such as smoking), which are related to both diagnoses. Further, the interactions of these risk factors appear to significantly influence impairments of lung function at the beginning of adult life, and potential subsequent disease.
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Barbee R.A., Dodge R., Lebowitz M.D., et al. (1985): The epidemiology of asthma. Chest, 87 (Suppl.): 21S–25S.
Blair H. (1977): Natural history of childhood asthma. Arch. Dis. Child., 52: 613–619.
Bronnimann S. and Burrows B. (1986): A prospective study of the natural history of asthma. Chest, 30: 480–484.
Britton W.J., Woolcock A.J., Peat J.K. et al. (1986): Prevalence of bronchial hyperresponsiveness in children: The relationship between asthma and skin reactivity to allergens in two communities. Int. J. Epidemiol., 15: 202–208.
Bufum W.P. (1966): Prognosis of asthma in childhood. Am. J. Dis. Child., 112: 21–27.
Burrows B. and Tuussig L. (1980): As the twig is bent, the tree inclines. (Perhgs). (Editorial) Am. Rev. Respir. Dis., 122: 813–816.
Burrows B., Lebowitz M.D. and Barbee R. (1976): Respitory disorders and allergy skin-test reactions. Ann. Int Med., 84(2): 134–139.
Burrows B., Martinez F.D., Halonen M. et al. (1989): Association of asthma with serum IgE levels and skin-test reactivity to allergens. New England J. Med., 320: 271–277
Dawson B., Illsley R., Harobin G. et al. (1969): A survey of childhood asthma in Abeerdeen. Lancet, 2: 321.
Dodge R.R. and Burrows B. (1980): The prevalence and incidence of asthma and asthma-like symptoms in a general population sample. Am Rev Respir Dis 122: 567–575.
Dodge R., Cline M.G. and Burrows B. (1986): Comparison of asthma, emphysema, and chronic bronchitis diagnoses in a general population sample. Am. Rev. Respir. Dis., 133: 981–986.
Freeman G.L. and Johnson S. (1964): Allergic diseases in adolescents. I. Description of survey; prevalence of allergy. Am. J. Dis. Child., 107: 549.
Graham P.J., Rutter M.L. and Yule W. (1967): Childhood asthma: A psychosomatic disorder? Brit. J. Prev. Soc. Med., 21: 78.
Gregg I. (1983): Epidemiological Aspects. In: Clark TJH, Godfreg S. (Eds.): Asthma. Philadelphia: WB Saunders Co.
Halonen M., Barbee R.A., Lebowitz M.D. and Burrows B. (1982): An epidemiologic study of the interrelationships of total serum IgE, allergy skin test reactivity and eosinophilia. J. Allergy Clin. Immunol., 69: 221–228.
Holland W.W., Halil T., Bennett E.A. et al. (1969). Factors influencing the onset of chronic respiratory disease. Brit. Med. J., 2: 205–208.
Horwood L.J., Fergusson D.M. and Shannon F.T. (1985): Social and familial factors in the development of early childhood asthma. J. Pediatr., 75: 859–868.
Lebowitz M.D., Barbee R. and Burrows B. (1984): Family concordance of IgE, atopy and disease. J. Allergy Clin. Immunol., 73: 259–266.
Lebowitz M. and Burrows B. (1986): Risk factors in induction of lung disease: An epidemiological approach. In: Stein TP, Weinbaum G. (Eds.) Mechanisms of Lung Injury, Philadelphia, Stickley Publ. Co.
Lebowitz M.D. (1983): Health effects of indoor pollution. Ann. Rev. Public Health, 4: 203–221.
Lebowitz M.D. (1977): The relationship of socio-environmental factors to the prevalence of obstructive lung problems and other chronic conditions. J. Chronic Dis., 30: 599–611.
Lebowitz M.D., Knudson R.J. and Burrows B. (1975): The Tucson epidemiology study of chronic obstructive lung disease. I. Methodology and prevalence of disease. Am. J. Epidemiol., 102: 137–152.
Lebowitz M.D., Holberg C.J., Knudson R.J. et al. (1987): Longitudinal study of pulmonary function development in childhood, adolescence and early adulthood. Am Rev. Respir. Dis., 136: 69–75.
Lebowitz M.D. and Burrows B. (1976): Respiratory symptoms related to smoking habits in family members. Chest, 69: 48–50.
Lebowitz M.D. and Quackenboss J.J. (1989): The effects on environmental tobacco smoke on pulmonary function. Int. Arch. Occ. Environ. Hlth., (Suppl.): 149–152.
Lebowitz M.D., Burrows B., Traver G.A., et al. (1985): Methodological considerations of epidemiological diagnoses in respiratory diseases. Eur. J. Epidemiol., 1(3): 188–192.
Leeder S.R., Corkhill R.T., Irwig L.M. et. al. (1976): Influence of family factors on asthma and wheezing during the first five years of life. Br. J. Prev. Soc. Med., 30: 213–218.
Mark J.D., McBride J.T., Brooks J.G. et al. (1986): Airway hyperreactivity and a history of clinical manifestations of asthma in childhood. Pediatr. Pulmonol., 2: 170–174.
Martinez F., Antognoni C, Macri F., et al. (1985): Distribution of bronchial responsiveness to a constrictive drug in a random pediatric population sample. (Abst) Am. Rev. Respir. Dis., 131(# 4, part 2): A242.
Martinez F.D., Antognoni G., Macri F., et al. (1988): Parental smoking enhances bronchial responsiveness in nine-year-old children. Am. Rev. Respir. Dis., 138: 518–523.
McConnochie K.M. and Roghmann K.J. (1986): Breast feeding and maternal smoking as predictors of wheezing in children age 6 to 10 years. Pediatr. Pulmonol., 2: 260–268.
McNicol K.N., Williams H.E., Allan J. et al. (1973): Spectrum of asthma in children: III. Psychological and social components. Br. Med. J., 4: 16–20.
Mitchell R.G. and Dawson B. (1973): Educational and social characteristics of children with asthma. Arch. Dis. Child. 48: 467–471.
Mok J.Y.Q. and Simpson H. (1984): Symptoms, atopy, and bronchial reactivity after lower respiratory infection in infancy. Arch. Dis. Child., 59: 299–305.
Murray A.B. and Morrison B.J. (1986): The effect of cigarette smoke from the mother on bronchial responsiveness and severity of symptoms in children with asthma. J. Allergy Clin. Immunol., 77(4): 575–581.
Newacheck P.W., Budetti P.P. and Halton N. (1986): Trends in activity- limiting chronic conditions among children. Am. J. Public Health, 76: 178–184.
Park E.S., Golding J., Carswekk F. et al. (1986): Preschool wheezing and prognosis at 10. Arch. Dis. Child., 61: 642–646.
Riedel F. and von der Hardt H. (1986): Bronchial sensitivity to inhaled histamine in healthy, nonatopic children. Pediatr. Pulmonol., 2: 15–18.
Sibbald B., Horn M.E.C., Brain E.A. et al. (1980): Genetic factors in childhood asthma. Thorax, 35: 671–674.
Taussig L.M., Smith S.M. and Blumenfeld R. (1981): Chronic bronchitis in childhood: What is it? Pediatrics, 67: 1–5.
Weiss S.T., Tager I.B., Weiss J.W. et al. (1984): Airways responsiveness in a population sample of adults and children. Am. Rev. Respir. Dis., 129: 898–902.
Woolcock A.J., Peat J.K., Leeder S.R. et al. (1984): The development of lung function in Sydney children: Effects of respiratory illness and smoking. Eur. J. Respir. Dis., 132 (Suppl.).
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Lebowitz, M.D., Holberg, C.J. & Martinez, F.D. A longitudinal study of risk factors in asthma and chronic bronchitis in childhood. Eur J Epidemiol 6, 341–347 (1990). https://doi.org/10.1007/BF00151706
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DOI: https://doi.org/10.1007/BF00151706