Skip to main content

A Physical Model of Inspiratory Flow Limitation in Awake Healthy Subjects

  • Conference paper
Book cover Post-Genomic Perspectives in Modeling and Control of Breathing

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 551))

Abstract

The obstructive syndrome of sleep apnea/hypopnea is characterized by repeated partial or total obstructions of the upper airways (UA) [1] resulting in intermittent asphyxia and repeated micro-arousals. Sleep disordered breathing affects about 9% of males and 4.5% of females between the ages of 30 and 60 years [2], 15% to 20% of elderly people [3] and 5% to 10% of children [4]. Sleep apnea and hypopnea events are easily identified while more subtle events, such as inspiratory flow limitation episodes, are difficult to detect. Flow limitation is the result of a partial occlusion of the upper airway during sleep.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Farré R., Peslin R., Rotger M., and Navajas D. Inspiratory Dynamic Obstruction Detected by Forced Oscillation during CPAP, A Model Study. Am. J. Respi. Crit. Care Med., 1997, 155: 952–956.

    Google Scholar 

  2. Young T., Palta M., Dempsey J., Skatrud J., et al. The Occurrence of Sleep Disordered Breathing Among Middle-aged Adults. New Engl. J. Med., 1993, 328: 1230–1235.

    Article  CAS  PubMed  Google Scholar 

  3. Ancoli-Israel S. Epidemiology of Sleep Disorders. Clin. Geriat. Med., 1989, 5: 347–362.

    CAS  Google Scholar 

  4. Guilleminault C. and Pelayo R. Sleep-disordered Breathing in Children. Ann. Med., 1998, 30: 350–6.

    Article  CAS  PubMed  Google Scholar 

  5. Horner R. L., Innes J. A., Murphy K., Guz A. Evidence for Reflex Upper Airway Dilator Muscle Activation by Sudden Negative Airway Pressure in Man. J Physiol (London), 1991, 436: 15–29.

    CAS  PubMed  Google Scholar 

  6. Remmers J. E., deGroot W. J., Sauerland E. K., and Anch A. M. Pathogenesis of Upper Airway Occlusion During Sleep. J Appl Physiol, 1978, 44: 931–938.

    CAS  PubMed  Google Scholar 

  7. Tantucci C., Mehiri S., Duguet A., Similowski T. Arnulf I., Zelter M., Derenne J.P., Milic-Emili J. Application of Negative Expiratory Pressure During Expiration and Activity of Genioglossus in Humans. J Appl Physiol, 1998, 84: 1076–82.

    CAS  PubMed  Google Scholar 

  8. Tangel D. J., Mezzanotte M. S., White D. P. Influence of Sleep on Tensor Palatini EMG and Upper Airway Resistance in Normal Men. J Appl Physiol, 1991, 70: 2574–81.

    CAS  PubMed  Google Scholar 

  9. Hosselet J. J., Norman R. G., Ayappa I., and Papoport D. Detection of Flow Limitation with Nasal Cannula/Pressure Transducer System. Am J Respir Crit Care Med, 1998, 157: 1461–1467.

    CAS  PubMed  Google Scholar 

  10. Clark S. A., Wilson C. R., Satoh M., Pegelow D., Dempsey J. A. Assessment of Inspiratory Flow Limitation Invasively and Noninvasively During Sleep. Am J Respir Crit Care Med. 1998, 158: 713–22.

    CAS  PubMed  Google Scholar 

  11. Kaplan V., Zhang J. N., Russi E. W., Bloch K. E. Detection of inspiratory flow limitation during sleep by computer assisted respiratory inductive plethysmography. Eur Respir J, 2000, 15: 570–578.

    Article  CAS  PubMed  Google Scholar 

  12. Aittokallio T., Saaresranta T., Polo-Kantola P., Nevalainen O., and Polio O. Analysis of Inspiratory Flow Shapes in Patients with Partial Upper-airway Obstruction During Sleep. Chest 2001; 119: 37–44.

    Article  CAS  PubMed  Google Scholar 

  13. Benchetrit G., Shea S. A., Pham Dinh T., Bodcco S., Baconnier P., Guz, A. Individuality of Breathing Patterns in Adults Assessed Over the Time. Respir. Physio, 1989, 75:199–210.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Kluwer Academic/Plenum Publishers, New York

About this paper

Cite this paper

Sabil, A., Eberhard, A., Baconnier, P., Benchetrit, G. (2004). A Physical Model of Inspiratory Flow Limitation in Awake Healthy Subjects. In: Champagnat, J., Denavit-Saubié, M., Fortin, G., Foutz, A.S., Thoby-Brisson, M. (eds) Post-Genomic Perspectives in Modeling and Control of Breathing. Advances in Experimental Medicine and Biology, vol 551. Springer, Boston, MA. https://doi.org/10.1007/0-387-27023-X_32

Download citation

Publish with us

Policies and ethics