Abstract
The obstructive syndrome of sleep apnea/hypopnea is characterized by repeated partial or total obstructions of the upper airways (UA) [1] resulting in intermittent asphyxia and repeated micro-arousals. Sleep disordered breathing affects about 9% of males and 4.5% of females between the ages of 30 and 60 years [2], 15% to 20% of elderly people [3] and 5% to 10% of children [4]. Sleep apnea and hypopnea events are easily identified while more subtle events, such as inspiratory flow limitation episodes, are difficult to detect. Flow limitation is the result of a partial occlusion of the upper airway during sleep.
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Farré R., Peslin R., Rotger M., and Navajas D. Inspiratory Dynamic Obstruction Detected by Forced Oscillation during CPAP, A Model Study. Am. J. Respi. Crit. Care Med., 1997, 155: 952–956.
Young T., Palta M., Dempsey J., Skatrud J., et al. The Occurrence of Sleep Disordered Breathing Among Middle-aged Adults. New Engl. J. Med., 1993, 328: 1230–1235.
Ancoli-Israel S. Epidemiology of Sleep Disorders. Clin. Geriat. Med., 1989, 5: 347–362.
Guilleminault C. and Pelayo R. Sleep-disordered Breathing in Children. Ann. Med., 1998, 30: 350–6.
Horner R. L., Innes J. A., Murphy K., Guz A. Evidence for Reflex Upper Airway Dilator Muscle Activation by Sudden Negative Airway Pressure in Man. J Physiol (London), 1991, 436: 15–29.
Remmers J. E., deGroot W. J., Sauerland E. K., and Anch A. M. Pathogenesis of Upper Airway Occlusion During Sleep. J Appl Physiol, 1978, 44: 931–938.
Tantucci C., Mehiri S., Duguet A., Similowski T. Arnulf I., Zelter M., Derenne J.P., Milic-Emili J. Application of Negative Expiratory Pressure During Expiration and Activity of Genioglossus in Humans. J Appl Physiol, 1998, 84: 1076–82.
Tangel D. J., Mezzanotte M. S., White D. P. Influence of Sleep on Tensor Palatini EMG and Upper Airway Resistance in Normal Men. J Appl Physiol, 1991, 70: 2574–81.
Hosselet J. J., Norman R. G., Ayappa I., and Papoport D. Detection of Flow Limitation with Nasal Cannula/Pressure Transducer System. Am J Respir Crit Care Med, 1998, 157: 1461–1467.
Clark S. A., Wilson C. R., Satoh M., Pegelow D., Dempsey J. A. Assessment of Inspiratory Flow Limitation Invasively and Noninvasively During Sleep. Am J Respir Crit Care Med. 1998, 158: 713–22.
Kaplan V., Zhang J. N., Russi E. W., Bloch K. E. Detection of inspiratory flow limitation during sleep by computer assisted respiratory inductive plethysmography. Eur Respir J, 2000, 15: 570–578.
Aittokallio T., Saaresranta T., Polo-Kantola P., Nevalainen O., and Polio O. Analysis of Inspiratory Flow Shapes in Patients with Partial Upper-airway Obstruction During Sleep. Chest 2001; 119: 37–44.
Benchetrit G., Shea S. A., Pham Dinh T., Bodcco S., Baconnier P., Guz, A. Individuality of Breathing Patterns in Adults Assessed Over the Time. Respir. Physio, 1989, 75:199–210.
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© 2004 Kluwer Academic/Plenum Publishers, New York
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Sabil, A., Eberhard, A., Baconnier, P., Benchetrit, G. (2004). A Physical Model of Inspiratory Flow Limitation in Awake Healthy Subjects. In: Champagnat, J., Denavit-Saubié, M., Fortin, G., Foutz, A.S., Thoby-Brisson, M. (eds) Post-Genomic Perspectives in Modeling and Control of Breathing. Advances in Experimental Medicine and Biology, vol 551. Springer, Boston, MA. https://doi.org/10.1007/0-387-27023-X_32
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DOI: https://doi.org/10.1007/0-387-27023-X_32
Publisher Name: Springer, Boston, MA
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