Regular ArticleThe Elimination Half-Life of Urinary Cotinine in Children of Tobacco-Smoking Mothers
References (0)
Cited by (46)
Use of a physiologically-based pharmacokinetic model to explore the potential disparity in nicotine disposition between adult and adolescent nonhuman primates
2020, Toxicology and Applied PharmacologyCitation Excerpt :Urinary clearance rates (half-lives) of cotinine in newborns whose mothers smoked tobacco have been reported (Etzel et al., 1985; Dempsey et al., 2000). In other studies, infants and youth were exposed to second hand smoke, then placed in a smoke-free environment before urine collection, and the urinary clearance of cotinine was calculated from the collected samples (Collier et al., 1994; Leong et al., 1998). These reported urinary half-lives were quite variable and conflicting, reflecting the shortcomings in using these opportunistic methods.
Effects of Smoking Exposure in Infants on Gastroesophageal Reflux as a Function of the Sleep–Wakefulness State
2018, Journal of PediatricsCitation Excerpt :In infants from nonsmoking mothers, paternal smoking was the most significantly related determinant of measurable levels of urinary cotinine. In neonates, Etzel et al found an averaged cotinine half-life of 68 hours (range: 37-160 hours), whereas Leong et al found a median half-life of 28.3 hours (range: 6-259 hours) in infants.60,61 In the present study, our assay's limit of detection (1 ng/mL) enabled us to measure any exposure to nicotine.
Gender differences in cadmium and cotinine levels in prepubertal children
2015, Environmental ResearchMedico-social aspects of patients with bronchial asthma
2015, KontaktCitation Excerpt :Nicotine metabolite cotinine is a bio-marker of nicotine changes. It is half-life for breaking down was longer (17–24 h) than nicotine (2–3 h) [73,74]. Cotinine (nicotine metabolite) can be detected in urine, saliva, blood and hair [75].
Perinatal nicotine/smoking exposure and carotid chemoreceptors during development
2013, Respiratory Physiology and NeurobiologyCitation Excerpt :The authors did not find any effect of maternal smoking on the ventilatory response to hypoxia in either active or quiet sleep at any age, although arousal responses were depressed during quiet sleep. Lewis and Bosque (1995) found that the ventilatory responses to hypoxia (13%, 15% and 17% O2) were similar in smoking-exposed and non-exposed infants studied at 8–12 weeks of age. Nevertheless, these authors found that a higher proportion of infants of smokers failed to awake upon the hypoxic challenge, when compared with control infants.
- f1
Author for correspondence.