Regular ArticleA Comparative Study of the Effects of Citric Acid, Capsaicin and Resiniferatoxin on the Cough Challenge in Guinea-pig and Man
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2020, CellCitation Excerpt :We chose the organic fraction because the polyketide mycolactone of M. ulcerans is also isolated via chloroform:methanol extraction (George et al., 1998) and because Mtb has a lipid and organic metabolite rich cell wall with many active molecules (Jankute et al., 2015). We then used an established model of cough induction, namely, transient exposure of unrestrained, naive, healthy guinea pigs to noxious molecules (Laude et al., 1993; Tanaka and Maruyama, 2005) via a nebulizer and WBP analysis to test if the Mtb extract could trigger cough. As an independent control, we exposed guinea pigs to 0.4 M citric acid, a known cough agonist (Laude et al., 1993; Morice et al., 2007).
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